Association between Low Cord Serum Cortisol Level and Transient Tachypnea of the Newborn in Late Preterm and Term Neonates Delivered by Elective Cesarean Section.
Am J Perinatol
; 39(11): 1254-1260, 2022 08.
Article
em En
| MEDLINE
| ID: mdl-33454947
ABSTRACT
OBJECTIVE:
Transient tachypnea of the newborn (TTN), a common neonatal respiratory morbidity, is associated with failure of adequate clearance of fetal lung fluid. Glucocorticoids have an important role in lung maturity and the mechanisms of lung fluid clearance. The aim of this study is to assess the association between umbilical cord cortisol levels and transient TTN in late preterm and term neonates delivered by elective cesarean section (CS). STUDYDESIGN:
A case-control study of 37 newborns diagnosed with TTN (cases) was compared with 40 healthy newborns (controls). All infants were delivered by elective CS without labor. Umbilical cord cortisol levels were measured using enzyme-linked immunosorbent assay.RESULTS:
Mean cord cortisol levels were significantly lower in cases than controls (131.36 vs. 233.32 nmol/L, p = 0.0001; odds ratio [OR] = 3.7; 95% confidence interval [CI] 1.40-9.53), respectively. Cord serum cortisol correlated inversely with the duration of tachypnea and the respiratory rate (r = - 0.678 and -0.535, respectively).CONCLUSION:
Umbilical cord cortisol levels are significantly lower in newborns with transient TTN, and lower cortisol levels are associated with an increased respiratory rate and longer duration of admission. Antenatal glucocorticoids can be recommended for late preterm delivered by CS. KEY POINTS · Umbilical cord cortisol levels were lower in late preterm infants with TTN.. · Late preterm newborn with severe TTN and NICU hospitalization have lower cord cortisol levels.. · Antenatal glucocorticoids can be recommended for late preterm delivered by CS..
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Síndrome do Desconforto Respiratório do Recém-Nascido
/
Taquipneia Transitória do Recém-Nascido
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Newborn
/
Pregnancy
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article