NMR-Based Structural Characterization of a Two-Disulfide-Bonded Analogue of the FXIIIa Inhibitor Tridegin: New Insights into Structure-Activity Relationships.

Schmitz, Thomas; Paul George, Ajay Abisheck; Nubbemeyer, Britta; Bäuml, Charlotte A; Steinmetzer, Torsten; Ohlenschläger, Oliver; Biswas, Arijit; Imhof, Diana

Schmitz, Thomas; Paul George, Ajay Abisheck; Nubbemeyer, Britta; Bäuml, Charlotte A; Steinmetzer, Torsten; Ohlenschläger, Oliver; Biswas, Arijit; Imhof, Diana.

Afiliação

Schmitz T; Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany.
Paul George AA; Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany.
Nubbemeyer B; BioSolveIT GmbH, An der Ziegelei 79, D-53757 Sankt Augustin, Germany.
Bäuml CA; Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany.
Steinmetzer T; Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany.
Ohlenschläger O; Institute of Pharmaceutical Chemistry, Philipps University of Marburg, Marbacher Weg 6, 35032 Marburg, Germany.
Biswas A; Leibniz Institute on Aging-Fritz-Lipmann-Institute, Beutenbergstr. 11, D-07745 Jena, Germany.
Imhof D; Institute of Experimental Hematology and Transfusion Medicine, University Hospital Bonn, Sigmund-Freud-Str. 25, D-53127 Bonn, Germany.

Int J Mol Sci ; 22(2)2021 Jan 17.

Article em En | MEDLINE | ID: mdl-33477282

Assuntos

Fator XIIIa/antagonistas & inibidores; Espectroscopia de Ressonância Magnética/métodos; Proteínas e Peptídeos Salivares/farmacologia; Sequência de Aminoácidos; Animais; Dissulfetos/química; Fator XIIIa/metabolismo; Fibrinolíticos/farmacologia; Humanos; Isomerismo; Sanguessugas/metabolismo; Imageamento por Ressonância Magnética/métodos; Modelos Moleculares; Simulação de Dinâmica Molecular; Proteínas e Peptídeos Salivares/química; Proteínas e Peptídeos Salivares/metabolismo; Relação Estrutura-Atividade

Palavras-chave

NMR spectroscopy; coagulation cascade; coagulation factor XIIIa; cysteine-rich; disulfide bonds; peptide inhibitor; structure analysis; transglutaminase; tridegin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas e Peptídeos Salivares / Espectroscopia de Ressonância Magnética / Fator XIIIa Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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