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Systematic analysis using a bioinformatics strategy identifies SFTA1P and LINC00519 as potential prognostic biomarkers for lung squamous cell carcinoma.
Yin, Yu-Zhen; Yao, Shi-Hua; Li, Chun-Guang; Ma, Yu-Shui; Kang, Zhou-Jun; Zhang, Jia-Jia; Jia, Cheng-You; Hou, Li-Kun; Qin, Shan-Shan; Fan, Xin; Zhang, Han; Yang, Meng-Die; Zhang, Dan-Dan; Lu, Gai-Xia; Wang, Hui-Min; Gu, Li-Peng; Tian, Lin-Lin; Wang, Pei-Yao; Cao, Ping-Sheng; Wu, Wei; Cao, Zi-Yang; Lv, Zhong-Wei; Shi, Bo-Wen; Wu, Chun-Yan; Jiang, Geng-Xi; Fu, Da; Yu, Fei.
Afiliação
  • Yin YZ; Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
  • Yao SH; Shanghai Clinical College, Anhui Medical University Hefei 230032, China.
  • Li CG; Department of Thoracic Surgery, Navy Military Medical University Affiliated Changhai Hospital Shanghai 200433, China.
  • Ma YS; Department of Thoracic Surgery, Navy Military Medical University Affiliated Changhai Hospital Shanghai 200433, China.
  • Kang ZJ; Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
  • Zhang JJ; Pancreatic Cancer Institute, Fudan University Shanghai 200032, China.
  • Jia CY; Department of Pancreatic and Hepatobiliary Surgery, Cancer Hospital, Fudan University Shanghai Cancer Center Shanghai 200032, China.
  • Hou LK; Department of Emergency, Navy Military Medical University Affiliated Changhai Hospital Shanghai 200433, China.
  • Qin SS; Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
  • Fan X; Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
  • Zhang H; Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai 200433, China.
  • Yang MD; Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
  • Zhang DD; Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
  • Lu GX; Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
  • Wang HM; Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
  • Gu LP; Central Laboratory for Medical Research, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
  • Tian LL; Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
  • Wang PY; Central Laboratory for Medical Research, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
  • Cao PS; Central Laboratory for Medical Research, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
  • Wu W; Central Laboratory for Medical Research, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
  • Cao ZY; Central Laboratory for Medical Research, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
  • Lv ZW; Central Laboratory for Medical Research, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
  • Shi BW; Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai 200433, China.
  • Wu CY; Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai 200433, China.
  • Jiang GX; Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
  • Fu D; Department of Thoracic Surgery, Navy Military Medical University Affiliated Changhai Hospital Shanghai 200433, China.
  • Yu F; Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai 200433, China.
Am J Transl Res ; 13(1): 168-182, 2021.
Article em En | MEDLINE | ID: mdl-33527016
ABSTRACT
Lung cancer has high incidence and mortality rates, in which lung squamous cell carcinoma (LUSC) is a primary type of non-small cell lung carcinoma (NSCLC). The aim of our study was to discover long non-coding RNAs (lncRNAs) associated with diagnose and prognosis for LUSC. RNA sequencing data obtained from LUSC samples were extracted from The Cancer Genome Atlas database (TCGA). Two prognosis-associated lncRNAs (including SFTA1P and LINC00519) were selected from LUSC samples, and the expression levels were also verified to be associated abnormal in LUSC clinical samples. Our findings demonstrate that lncRNAs SFTA1P and LINC00519 exert important functions in human LUSC and may serve as new targets for LUSC diagnosis and therapy.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article