Diagnostic Biopsy via In-Office Frozen Sections for Clinical Nonmelanoma Skin Cancer.
Dermatol Surg
; 47(2): 194-199, 2021 02 01.
Article
em En
| MEDLINE
| ID: mdl-33565773
ABSTRACT
BACKGROUND:
Treatment of nonmelanoma skin cancer (NMSC) by Mohs surgery has traditionally relied on previous pathologic evaluation of paraffin-embedded tissue. Tissue processing by frozen sections allows for expedited diagnosis and treatment; however, data on its accuracy are limited.OBJECTIVE:
To measure the accuracy and outcomes of biopsy via frozen sections for clinical NMSC.METHODS:
Biopsies of clinical NMSCs processed via frozen sections with in-office diagnosis rendered by one Mohs surgeon were retrospectively reviewed by one board-certified dermatopathologist. Discordant diagnoses were re-read in blinded fashion by both physicians. If still discordant, final diagnosis was determined by consensus discussion. Inter-rater reliability was calculated using Cohen's kappa statistic.RESULTS:
Two hundred ninety-seven lesions from 208 patients were included. Correlation between in-office and final diagnosis was 0.876 indicating "almost perfect" concordance. Sensitivity and specificity of in-office diagnosis for detecting malignancy were 98.1% and 94.4%. Seven cases (2.0%) had a clinically relevant change in final diagnosis, but appropriate treatment had been rendered. Two benign lesions (0.7%) initially diagnosed as malignant underwent excision.CONCLUSION:
In-office biopsy via frozen sections is highly accurate in confirming NMSC. This practice may speed diagnosis and treatment thus improving outcomes and patient satisfaction.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
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Carcinoma Basocelular
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Carcinoma de Células Escamosas
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Cirurgia de Mohs
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Ceratose Actínica
Tipo de estudo:
Diagnostic_studies
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Evaluation_studies
/
Observational_studies
Limite:
Aged
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article