ZMYND8 preferentially binds phosphorylated EZH2 to promote a PRC2-dependent to -independent function switch in hypoxia-inducible factor-activated cancer.

Tang, Bo; Sun, Rui; Wang, Dejie; Sheng, Haoyue; Wei, Ting; Wang, Liguo; Zhang, Jun; Ho, Thai H; Yang, Lu; Wei, Qiang; Huang, Haojie

Tang, Bo; Sun, Rui; Wang, Dejie; Sheng, Haoyue; Wei, Ting; Wang, Liguo; Zhang, Jun; Ho, Thai H; Yang, Lu; Wei, Qiang; Huang, Haojie.

Afiliação

Tang B; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, 610041 Chengdu, China.
Sun R; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905.
Wang D; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905.
Sheng H; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905.
Wei T; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905.
Wang L; Department of Urology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Zhang J; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Ho TH; Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine and Science, Rochester, MN 55905.
Yang L; Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine and Science, Rochester, MN 55905.
Wei Q; Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine and Science, Scottsdale, AZ 85259.
Huang H; Division of Hematology and Oncology, Department of Internal Medicine, Mayo Clinic College of Medicine and Science, Phoenix, AZ 85054.

Proc Natl Acad Sci U S A ; 118(8)2021 02 23.

Article em En | MEDLINE | ID: mdl-33593912

Assuntos

Carcinoma de Células Renais/patologia; Movimento Celular; Proteína Potenciadora do Homólogo 2 de Zeste/metabolismo; Hipóxia/fisiopatologia; Neoplasias Renais/patologia; Complexo Repressor Polycomb 2/metabolismo; Proteínas Supressoras de Tumor/metabolismo; Biomarcadores Tumorais/genética; Biomarcadores Tumorais/metabolismo; Carcinoma de Células Renais/genética; Carcinoma de Células Renais/metabolismo; Proliferação de Células; Cromatina/genética; Cromatina/metabolismo; Proteína Potenciadora do Homólogo 2 de Zeste/genética; Proteína Forkhead Box M1/genética; Proteína Forkhead Box M1/metabolismo; Regulação Neoplásica da Expressão Gênica; Humanos; Neoplasias Renais/genética; Neoplasias Renais/metabolismo; Metaloproteinases da Matriz/genética; Metaloproteinases da Matriz/metabolismo; Fosforilação; Complexo Repressor Polycomb 2/genética; Prognóstico; Taxa de Sobrevida; Células Tumorais Cultivadas; Proteínas Supressoras de Tumor/genética

Palavras-chave

EZH2; PRC2; ZMYND8; cancer; hypoxia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma de Células Renais / Movimento Celular / Proteínas Supressoras de Tumor / Complexo Repressor Polycomb 2 / Proteína Potenciadora do Homólogo 2 de Zeste / Neoplasias Renais / Hipóxia Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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