Modulation of lanosterol synthase drives 24,25-epoxysterol synthesis and oligodendrocyte formation.

Hubler, Zita; Friedrich, Ryan M; Sax, Joel L; Allimuthu, Dharmaraja; Gao, Farrah; Rivera-León, Adrianna M; Pleshinger, Matthew J; Bederman, Ilya; Adams, Drew J

Hubler, Zita; Friedrich, Ryan M; Sax, Joel L; Allimuthu, Dharmaraja; Gao, Farrah; Rivera-León, Adrianna M; Pleshinger, Matthew J; Bederman, Ilya; Adams, Drew J.

Afiliação

Hubler Z; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Friedrich RM; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Sax JL; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Allimuthu D; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Gao F; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Rivera-León AM; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Pleshinger MJ; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Bederman I; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Adams DJ; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address: drew.adams@case.edu.

Cell Chem Biol ; 28(6): 866-875.e5, 2021 06 17.

Article em En | MEDLINE | ID: mdl-33636107

Assuntos

Colesterol/análogos & derivados; Transferases Intramoleculares/metabolismo; Oligodendroglia/metabolismo; Animais; Células Cultivadas; Colesterol/biossíntese; Colesterol/química; Masculino; Camundongos; Oligodendroglia/citologia

Palavras-chave

cholesterol biosynthesis; epoxycholesterol; epoxycholesterol shunt; lanosterol synthase; multiple sclerosis; oligodendrocyte; remyelination; sterol signaling; target validation

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligodendroglia / Colesterol / Transferases Intramoleculares Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google