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Effects of Onabotulinum Toxin A on Gait in Parkinson's Disease Patients with Foot Dystonia.
Huang, Pei; Li, Yuan-Yuan; Park, Jung E; Huang, Ping; Xiao, Qin; Wang, Ying; Chen, Sheng; Chen, Sheng-Di; Liu, Jun; Wu, Yi-Wen.
Afiliação
  • Huang P; Department of Neurology, Institute of Neurology, Ruijin Hospital affiliated with Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Li YY; Department of Neurology, Institute of Neurology, Ruijin Hospital affiliated with Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Park JE; Department of Neurology, Dongguk University Ilsan Hospital, Goyang, Republic of Korea.
  • Huang P; Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases with Integrated Chinese-Western Medicine, Shanghai Institute of Traumatology and Orthopaedics, Department of Orthopaedics, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China.
  • Xiao Q; Department of Neurology, Institute of Neurology, Ruijin Hospital affiliated with Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Wang Y; Department of Neurology, Institute of Neurology, Ruijin Hospital affiliated with Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Chen S; Department of Neurology, Institute of Neurology, Ruijin Hospital affiliated with Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Chen SD; Department of Neurology, Institute of Neurology, Ruijin Hospital affiliated with Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Liu J; Department of Neurology, Institute of Neurology, Ruijin Hospital affiliated with Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Wu YW; Department of Neurology, Institute of Neurology, Ruijin Hospital affiliated with Shanghai Jiaotong University School of Medicine, Shanghai, China.
Can J Neurol Sci ; 49(1): 123-128, 2022 01.
Article em En | MEDLINE | ID: mdl-33685541
ABSTRACT
We investigated the effects of botulinum toxin on gait in Parkinson's disease (PD) patients with foot dystonia. Six patients underwent onabotulinum toxin A injection and were assessed by Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS), visual analog scale (VAS) of pain, Timed Up and Go (TUG), Berg Balance Test (BBT), and 3D gait analysis at baseline, 1 month, and 3 months. BFMDRS (p = 0.002), VAS (p = 0.024), TUG (p = 0.028), and BBT (p = 0.034) were improved. Foot pressures at Toe 1 (p = 0.028) and Midfoot (p = 0.018) were reduced, indicating botulinum toxin's effects in alleviating the dystonia severity and pain and improving foot pressures during walking in PD.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Toxinas Botulínicas Tipo A / Distonia Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Toxinas Botulínicas Tipo A / Distonia Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article