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Mitochondrial DNA enables AIM2 inflammasome activation and hepatocyte pyroptosis in nonalcoholic fatty liver disease.
Xu, Lu; Zhou, Jingyang; Che, Jinhui; Wang, Haihong; Yang, Weizhong; Zhou, Wuyuan; Zhao, Hongying.
Afiliação
  • Xu L; Department of Hepatopancreatobillary Surgery, Xuzhou City Cancer Hospital, Xuzhou, Jiangsu, China.
  • Zhou J; Class 182, Queen Mary School, Nanchang University, Nanchang, Jiangxi, China.
  • Che J; Department of Hepatopancreatobillary Surgery, Xuzhou City Cancer Hospital, Xuzhou, Jiangsu, China.
  • Wang H; Department of Hepatopancreatobillary Surgery, Xuzhou City Cancer Hospital, Xuzhou, Jiangsu, China.
  • Yang W; Department of Hepatopancreatobillary Surgery, Xuzhou City Cancer Hospital, Xuzhou, Jiangsu, China.
  • Zhou W; Department of Hepatopancreatobiliary Surgery, Xuzhou City Cancer Hospital, Gulou District, Xuzhou City, Jiangsu, China.
  • Zhao H; Department of Oncology, Xuzhou City Cancer Hospital, Xuzhou, Jiangsu, China.
Am J Physiol Gastrointest Liver Physiol ; 320(6): G1034-G1044, 2021 06 01.
Article em En | MEDLINE | ID: mdl-33728991
Mitochondria damage exacerbates NAFLD through trigerring AIM2 inflammasome activation and hepatocyte pyroptosis. This study provides novel insights into the underlying mechanisms of mitochondrial DNA synthesis in NAFLD and also suggests potential therapeutic targets for the treatment of NAFLD.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Hepatócitos / Proteínas de Ligação a DNA / Inflamassomos / Hepatopatia Gordurosa não Alcoólica / Piroptose Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Hepatócitos / Proteínas de Ligação a DNA / Inflamassomos / Hepatopatia Gordurosa não Alcoólica / Piroptose Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article