Plasma prevalence of anti-N-methyl-d-aspartate receptor IgG antibodies in early stages of psychosis.
Cien Saude Colet
; 26(3): 1085-1094, 2021 Mar.
Article
em En
| MEDLINE
| ID: mdl-33729361
ABSTRACT
We investigated the feasibility of including plasma anti-NMDAR antibody screening in the assessment of first-episode psychosis patients in an early intervention programme in the Southern hemisphere. Anti-NMDAR IgG antibodies were assessed by ELISA in 166 patients (64.0% men), 166 matched population-based controls and 76 patients' siblings (30.3% men). Fisher's exact test and ANOVA were performed. Positive anti-NMDAR antibody patients were more often observed in bipolar disorder (10.0%) than schizophrenia (2.4%) or psychotic depression (3.1%), although no significant differences were observed. Our results are not conclusive regarding the inclusion of plasma anti-NMDAR IgG antibodies in differential diagnostic protocols for psychosis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transtornos Psicóticos
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Esquizofrenia
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Transtorno Bipolar
Tipo de estudo:
Guideline
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article