Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress.

Zhang, Wuchang; Liu, Wei; Jia, Lingfei; Chen, Demeng; Chang, Insoon; Lake, Michael; Bentolila, Laurent A; Wang, Cun-Yu

Zhang, Wuchang; Liu, Wei; Jia, Lingfei; Chen, Demeng; Chang, Insoon; Lake, Michael; Bentolila, Laurent A; Wang, Cun-Yu.

Afiliação

Zhang W; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Laboratory of Molecular Signaling, Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Liu W; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Laboratory of Molecular Signaling, Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jia L; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Laboratory of Molecular Signaling, Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Chen D; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Laboratory of Molecular Signaling, Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Chang I; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Laboratory of Molecular Signaling, Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Lake M; Advanced Light Microscopy and Spectroscopy Laboratory, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Bentolila LA; Advanced Light Microscopy and Spectroscopy Laboratory, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Wang CY; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Laboratory of Molecular Signaling, Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, Henr

Mol Cell ; 81(10): 2148-2165.e9, 2021 05 20.

Article em En | MEDLINE | ID: mdl-33743195

Assuntos

Carcinoma de Células Escamosas/genética; Carcinoma de Células Escamosas/imunologia; Replicação do DNA/genética; Epigênese Genética; Histona Desmetilases/metabolismo; Imunidade/genética; Histona Desmetilases com o Domínio Jumonji/metabolismo; Estresse Fisiológico/genética; Animais; Linfócitos T CD8-Positivos/imunologia; Carcinoma de Células Escamosas/patologia; Linhagem Celular Tumoral; Quimiocinas/metabolismo; Homólogo 5 da Proteína Cromobox; Proteínas Cromossômicas não Histona/metabolismo; Dano ao DNA/genética; Células Epiteliais/metabolismo; Deleção de Genes; Humanos; Metástase Linfática; Camundongos Transgênicos; Invasividade Neoplásica; Células-Tronco Neoplásicas/metabolismo; Células-Tronco Neoplásicas/patologia; Receptor de Morte Celular Programada 1/metabolismo; Receptores CXCR3/metabolismo; Células Th1/imunologia

Palavras-chave

DNA replication stress; H3K9me3; KDM4A; PD-1 blockade; Phase separation; cancer stem cells; head and neck squamous cell carcinoma; heterochromatin condensates; immune surveillance; metastasis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estresse Fisiológico / Carcinoma de Células Escamosas / Epigênese Genética / Replicação do DNA / Histona Desmetilases / Histona Desmetilases com o Domínio Jumonji / Imunidade Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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