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Scalable Total Synthesis, IP3R Inhibitory Activity of Desmethylxestospongin B, and Effect on Mitochondrial Function and Cancer Cell Survival.
Podunavac, Masa; Mailyan, Artur K; Jackson, Jeffrey J; Lovy, Alenka; Farias, Paula; Huerta, Hernan; Molgó, Jordi; Cardenas, Cesar; Zakarian, Armen.
Afiliação
  • Podunavac M; Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, CA, 93106, USA.
  • Mailyan AK; Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, CA, 93106, USA.
  • Jackson JJ; Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, CA, 93106, USA.
  • Lovy A; Center for Integrative Biology, Faculty of Sciences, Geroscience Center for Brain Health and Metabolism, Universidad Mayor, Santiago, Chile.
  • Farias P; Center for Integrative Biology, Faculty of Sciences, Geroscience Center for Brain Health and Metabolism, Universidad Mayor, Santiago, Chile.
  • Huerta H; Center for Integrative Biology, Faculty of Sciences, Geroscience Center for Brain Health and Metabolism, Universidad Mayor, Santiago, Chile.
  • Molgó J; Université Paris-Saclay, CEA, Institut des Sciences du Vivant Frédéric Joliot, ERL CNRS n 9004, Département Médicaments et Technologies pour la Santé, Service d'Ingéniere Moléculaire pour Santé (SIMoS), Batiment 152, Point courrier 24, 91191, Gif-sur-Yvette, France.
  • Cardenas C; Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, CA, 93106, USA.
  • Zakarian A; Center for Integrative Biology, Faculty of Sciences, Geroscience Center for Brain Health and Metabolism, Universidad Mayor, Santiago, Chile.
Angew Chem Int Ed Engl ; 60(20): 11278-11282, 2021 05 10.
Article em En | MEDLINE | ID: mdl-33751770
ABSTRACT
The scalable synthesis of the oxaquinolizidine marine natural product desmethylxestospongin B is based on the early application of Ireland-Claisen rearrangement, macrolactamization, and a late-stage installation of the oxaquinolizidine units by lactam reduction. The synthesis serves as the source of material to investigate calcium signaling and its effect on mitochondrial metabolism in various cell types, including cancer cells.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Receptores de Inositol 1,4,5-Trifosfato / Mitocôndrias / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
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Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Receptores de Inositol 1,4,5-Trifosfato / Mitocôndrias / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article