Synthesis and biological evaluation of disulfides as anticancer agents with thioredoxin inhibition.

Wei, Xiangxu; Zhong, Miao; Wang, Song; Li, Lexun; Song, Zi-Long; Zhang, Junmin; Xu, Jianqiang; Fang, Jianguo

Wei, Xiangxu; Zhong, Miao; Wang, Song; Li, Lexun; Song, Zi-Long; Zhang, Junmin; Xu, Jianqiang; Fang, Jianguo.

Afiliação

Wei X; State Key Laboratory of Applied Organic Chemistry & College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Zhong M; State Key Laboratory of Applied Organic Chemistry & College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Wang S; State Key Laboratory of Applied Organic Chemistry & College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Li L; State Key Laboratory of Applied Organic Chemistry & College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Song ZL; State Key Laboratory of Applied Organic Chemistry & College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Zhang J; State Key Laboratory of Applied Organic Chemistry & College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China; School of Pharmacy, Lanzhou University, Lanzhou 730000, China. Electronic address: zhangjunmin@lzu.edu.cn.
Xu J; School of Life and Pharmaceutical Sciences & Panjin Institute of Industrial Technology, Dalian University of Technology, Panjin 124221, China.
Fang J; State Key Laboratory of Applied Organic Chemistry & College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. Electronic address: fangjg@lzu.edu.cn.

Bioorg Chem ; 110: 104814, 2021 05.

Article em En | MEDLINE | ID: mdl-33756234

Assuntos

Antineoplásicos/farmacologia; Dissulfetos/farmacologia; Tiorredoxinas/antagonistas & inibidores; Antineoplásicos/síntese química; Antineoplásicos/química; Apoptose/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Dissulfetos/síntese química; Dissulfetos/química; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Células HeLa; Humanos; Estrutura Molecular; Relação Estrutura-Atividade; Tiorredoxinas/metabolismo; Células Tumorais Cultivadas

Palavras-chave

Anticancer; Apoptosis; Disulfide; Oxidative stress; Thioredoxin

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiorredoxinas / Dissulfetos / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google