Synthesis and biological evaluation of naphthoquinone phenacylimidazolium derivatives.

Yuan, Jing; Liu, Zhanxiong; Zhang, Zhenfeng; Yan, Deyue; Zhang, Wanbin

Yuan, Jing; Liu, Zhanxiong; Zhang, Zhenfeng; Yan, Deyue; Zhang, Wanbin.

Afiliação

Yuan J; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Frontier Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China.
Liu Z; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Frontier Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China.
Zhang Z; School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China. Electronic address: zhenfeng@sjtu.edu.cn.
Yan D; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Frontier Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China.
Zhang W; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Frontier Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China; School of Pharmacy, Shanghai Jiao Tong University, 800

Bioorg Med Chem Lett ; 41: 127977, 2021 06 01.

Article em En | MEDLINE | ID: mdl-33766771

Assuntos

Antineoplásicos/farmacologia; Imidazóis/farmacologia; Naftoquinonas/farmacologia; Animais; Antineoplásicos/síntese química; Antineoplásicos/química; Apoptose/efeitos dos fármacos; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Linhagem Celular; Proliferação de Células/efeitos dos fármacos; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Imidazóis/síntese química; Imidazóis/química; Camundongos; Estrutura Molecular; Naftoquinonas/síntese química; Naftoquinonas/química; Relação Estrutura-Atividade

Palavras-chave

Antiproliferative; Antitumor; Imidazolium; Naphthoquinone; Phenacyl

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Naftoquinonas / Imidazóis / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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