DECO: a framework for jointly analyzing de novo and rare case/control variants, and biological pathways.

Nguyen, Tan-Hoang; He, Xin; Brown, Ruth C; Webb, Bradley T; Kendler, Kenneth S; Vladimirov, Vladimir I; Riley, Brien P; Bacanu, Silviu-Alin

Nguyen, Tan-Hoang; He, Xin; Brown, Ruth C; Webb, Bradley T; Kendler, Kenneth S; Vladimirov, Vladimir I; Riley, Brien P; Bacanu, Silviu-Alin.

Afiliação

Nguyen TH; Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
He X; The Department of Human Genetics, University of Chicago, IL 60637, USA; Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior, University of Chicago, Chicago, IL 60637, USA.
Brown RC; Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Webb BT; Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Kendler KS; Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Vladimirov VI; Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA; Department of Psychiatry & Behavioral Sciences, College of Medicine, Texas A&M University, College Station, TX, USA; and the Lieber Institute for Brain D
Riley BP; Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Bacanu SA; Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.

Brief Bioinform ; 22(5)2021 09 02.

Article em En | MEDLINE | ID: mdl-33791774

Assuntos

Predisposição Genética para Doença/genética; Mutação; Transtornos do Neurodesenvolvimento/genética; Esquizofrenia/genética; Biologia de Sistemas/métodos; Estudos de Casos e Controles; Simulação por Computador; Análise Mutacional de DNA/métodos; Humanos; Modelos Estatísticos; Mapeamento de Interação de Proteínas/métodos; Mapas de Interação de Proteínas/genética

Palavras-chave

de novo mutation; integrative analysis; neurodevelopmental disorder; neuropsychiatric disorder

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esquizofrenia / Predisposição Genética para Doença / Biologia de Sistemas / Transtornos do Neurodesenvolvimento / Mutação Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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