GCase and LIMP2 Abnormalities in the Liver of Niemann Pick Type C Mice.

van der Lienden, Martijn J C; Aten, Jan; Marques, André R A; Waas, Ingeborg S E; Larsen, Per W B; Claessen, Nike; van der Wel, Nicole N; Ottenhoff, Roelof; van Eijk, Marco; Aerts, Johannes M F G

van der Lienden, Martijn J C; Aten, Jan; Marques, André R A; Waas, Ingeborg S E; Larsen, Per W B; Claessen, Nike; van der Wel, Nicole N; Ottenhoff, Roelof; van Eijk, Marco; Aerts, Johannes M F G.

Afiliação

van der Lienden MJC; Department Medical Biochemistry, Leiden University, 2333 CC Leiden, The Netherlands.
Aten J; Department of Pathology, Amsterdam UMC, University of Amsterdam, 1100 DD Amsterdam, The Netherlands.
Marques ARA; Chronic Diseases Research Centre, Universidade NOVA de Lisboa, 1150-082 Lisbon, Portugal.
Waas ISE; Department of Pathology, Amsterdam UMC, University of Amsterdam, 1100 DD Amsterdam, The Netherlands.
Larsen PWB; Department of Pathology, Amsterdam UMC, University of Amsterdam, 1100 DD Amsterdam, The Netherlands.
Claessen N; Department of Pathology, Amsterdam UMC, University of Amsterdam, 1100 DD Amsterdam, The Netherlands.
van der Wel NN; Electron Microscopy Center Amsterdam, Department of Medical Biology, Amsterdam UMC, 1100 DD Amsterdam, The Netherlands.
Ottenhoff R; Department of Medical Biochemistry, Amsterdam UMC, University of Amsterdam, 1100 DD Amsterdam, The Netherlands.
van Eijk M; Department Medical Biochemistry, Leiden University, 2333 CC Leiden, The Netherlands.
Aerts JMFG; Department Medical Biochemistry, Leiden University, 2333 CC Leiden, The Netherlands.

Int J Mol Sci ; 22(5)2021 Mar 03.

Article em En | MEDLINE | ID: mdl-33802460

Assuntos

Glucosilceramidase/metabolismo; Fígado/metabolismo; Proteínas de Membrana Lisossomal/metabolismo; Doença de Niemann-Pick Tipo C/metabolismo; Receptores Depuradores/metabolismo; Animais; Transporte Biológico/fisiologia; Catepsina D/metabolismo; Linhagem Celular; Linhagem Celular Tumoral; Doença de Gaucher/metabolismo; Glucosilceramidas/metabolismo; Células Hep G2; Hepatócitos/metabolismo; Humanos; Lisossomos/metabolismo; Macrófagos/metabolismo; Camundongos; Camundongos Endogâmicos BALB C; Células RAW 264.7; Esfingomielinas/metabolismo

Palavras-chave

GCase; GPNMB; LIMP2; NPC; NPC1; lysosome; macrophage; storage

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Membrana Lisossomal / Receptores Depuradores / Doença de Niemann-Pick Tipo C / Glucosilceramidase / Fígado Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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