Knockdown of lncRNA PVT1 attenuated macrophage M1 polarization and relieved sepsis induced myocardial injury via miR-29a/HMGB1 axis.

Luo, Yuan-Yuan; Yang, Zhong-Qi; Lin, Xin-Feng; Zhao, Feng-Li; Tu, Hai-Tao; Wang, Ling-Jun; Wen, Min-Yong; Xian, Shao-Xiang

Luo, Yuan-Yuan; Yang, Zhong-Qi; Lin, Xin-Feng; Zhao, Feng-Li; Tu, Hai-Tao; Wang, Ling-Jun; Wen, Min-Yong; Xian, Shao-Xiang.

Afiliação

Luo YY; Department of Intensive Care Unit, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, PR China.
Yang ZQ; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, PR China.
Lin XF; Department of Intensive Care Unit, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, PR China.
Zhao FL; Department of Intensive Care Unit, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, PR China.
Tu HT; Department of Nephrology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, PR China.
Wang LJ; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, PR China. Electronic address: linjunn789@163.com.
Wen MY; Department of Intensive Care Unit, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, PR China. Electronic address: mmyon456@163.com.
Xian SX; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, PR China. Electronic address: shaaxx123@163.com.

Cytokine ; 143: 155509, 2021 07.

Article em En | MEDLINE | ID: mdl-33840587

Assuntos

Polaridade Celular; Técnicas de Silenciamento de Genes; Proteína HMGB1/metabolismo; Macrófagos/metabolismo; MicroRNAs/metabolismo; Miocárdio/patologia; RNA Longo não Codificante/metabolismo; Sepse/genética; Animais; Sequência de Bases; Polaridade Celular/genética; Testes de Função Cardíaca; Inflamação/genética; Inflamação/patologia; Lipopolissacarídeos; Masculino; Camundongos Endogâmicos C57BL; MicroRNAs/genética; RNA Longo não Codificante/genética; Transdução de Sinais; Regulação para Cima/genética

Palavras-chave

HMGB1; Macrophage polarization; Myocardial injury; Sepsis; lncRNA PVT1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polaridade Celular / Sepse / Proteína HMGB1 / MicroRNAs / Técnicas de Silenciamento de Genes / RNA Longo não Codificante / Macrófagos / Miocárdio Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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