CD169+ lymph node macrophages have protective functions in mouse breast cancer metastasis.
Cell Rep
; 35(2): 108993, 2021 04 13.
Article
em En
| MEDLINE
| ID: mdl-33852863
ABSTRACT
Although the contribution of macrophages to metastasis is widely studied in primary tumors, the involvement of macrophages in tumor-draining lymph nodes (LNs) in this process is less clear. We find CD169+ macrophages as the predominant macrophage subtype in naive LNs, which undergo proliferative expansion in response to tumor stimuli. CD169+ LN macrophage depletion, using an anti-CSF-1R antibody or clodronate-loaded liposomes, leads to increased metastatic burden in two mouse breast cancer models. The expansion of CD169+ macrophages is tightly connected to B cell expansion in tumor-draining LNs, and B cell depletion abrogates the effect of CD169+ macrophage absence on metastasis, indicating that the CD169+ macrophage anti-metastatic effects require B cell presence. These results reveal a protective role of CD169+ LN macrophages in breast cancer metastasis and raise caution for the use of drugs aiming at the depletion of tumor-associated macrophages, which might simultaneously deplete macrophages in tumor-draining LNs.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Lectina 1 Semelhante a Ig de Ligação ao Ácido Siálico
/
Neoplasias Pulmonares
/
Linfonodos
/
Macrófagos
/
Glândulas Mamárias Animais
/
Neoplasias Mamárias Experimentais
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article