Small-molecule inhibitors of carboxylesterase Notum.

Zhao, Yuguang; Jolly, Sarah; Benvegnu, Stefano; Jones, E Yvonne; Fish, Paul V

Zhao, Yuguang; Jolly, Sarah; Benvegnu, Stefano; Jones, E Yvonne; Fish, Paul V.

Afiliação

Zhao Y; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Oxford, OX3 7BN, UK.
Jolly S; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London, WC1E 6BT, UK.
Benvegnu S; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London, WC1E 6BT, UK.
Jones EY; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Oxford, OX3 7BN, UK.
Fish PV; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, Cruciform Building, Gower Street, London, WC1E 6BT, UK.

Future Med Chem ; 13(11): 1001-1015, 2021 06.

Article em En | MEDLINE | ID: mdl-33882714

Assuntos

Inibidores Enzimáticos/farmacologia; Esterases/antagonistas & inibidores; Bibliotecas de Moléculas Pequenas/farmacologia; Inibidores Enzimáticos/química; Esterases/metabolismo; Humanos; Modelos Moleculares; Estrutura Molecular; Bibliotecas de Moléculas Pequenas/química

Palavras-chave

Notum inhibitors; Wnt signaling; activity-based protein profiling; fragment screening; high-throughput screening; hit-finding strategies; structural biology; virtual screening

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Esterases / Bibliotecas de Moléculas Pequenas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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