Inhibition of interleukin-1ß plays a protective role in Alzheimer's disease by promoting microRNA-9-5p and downregulating targeting protein for xenopus kinesin-like protein 2.

Zhang, Yan-Yun; Dong, Li-Xia; Bao, Hai-Lan; Liu, Yu; An, Feng-Mao; Zhang, Guo-Wei

Zhang, Yan-Yun; Dong, Li-Xia; Bao, Hai-Lan; Liu, Yu; An, Feng-Mao; Zhang, Guo-Wei.

Afiliação

Zhang YY; College of Nursing, Inner Mongolia University for Nationalities, Tongliao 028000, Inner Mongolia Autonomous Region, PR China; Institute of Dementia, Inner Mongolia University for Nationalities, Tongliao 028000, Inner Mongolia, PR China.
Dong LX; College of Nursing, Inner Mongolia University for Nationalities, Tongliao 028000, Inner Mongolia Autonomous Region, PR China; Institute of Dementia, Inner Mongolia University for Nationalities, Tongliao 028000, Inner Mongolia, PR China.
Bao HL; College of Nursing, Inner Mongolia University for Nationalities, Tongliao 028000, Inner Mongolia Autonomous Region, PR China; Institute of Dementia, Inner Mongolia University for Nationalities, Tongliao 028000, Inner Mongolia, PR China.
Liu Y; College of Nursing, Inner Mongolia University for Nationalities, Tongliao 028000, Inner Mongolia Autonomous Region, PR China; Institute of Dementia, Inner Mongolia University for Nationalities, Tongliao 028000, Inner Mongolia, PR China.
An FM; Institute of Dementia, Inner Mongolia University for Nationalities, Tongliao 028000, Inner Mongolia, PR China; Inner Mongolia Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular System, Tongliao 028000, Inner Mongolia, PR China.
Zhang GW; College of Nursing, Inner Mongolia University for Nationalities, Tongliao 028000, Inner Mongolia Autonomous Region, PR China; Institute of Dementia, Inner Mongolia University for Nationalities, Tongliao 028000, Inner Mongolia, PR China. Electronic address: zhangguowei00542@163.com.

Int Immunopharmacol ; 97: 107578, 2021 Aug.

Article em En | MEDLINE | ID: mdl-33892301

Assuntos

Doença de Alzheimer/imunologia; Proteínas de Ciclo Celular/genética; Interleucina-1beta/metabolismo; MicroRNAs/metabolismo; Proteínas Associadas aos Microtúbulos/genética; Proteínas Nucleares/genética; Doença de Alzheimer/genética; Doença de Alzheimer/patologia; Precursor de Proteína beta-Amiloide/genética; Animais; Proteínas de Ciclo Celular/metabolismo; Modelos Animais de Doenças; Regulação para Baixo/imunologia; Feminino; Humanos; Camundongos; Camundongos Transgênicos; MicroRNAs/genética; Proteínas Associadas aos Microtúbulos/metabolismo; Proteínas Nucleares/metabolismo; Presenilina-1/genética; Transdução de Sinais/genética; Transdução de Sinais/imunologia; Regulação para Cima/imunologia

Palavras-chave

Alzheimer's disease; Interleukin-1ß; MicroRNA-9-5p; Neural function; Targeting protein for xenopus kinesin-like protein 2

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Proteínas de Ciclo Celular / MicroRNAs / Interleucina-1beta / Doença de Alzheimer / Proteínas Associadas aos Microtúbulos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google