Investigation of the role of matrix metalloproteinases in the genetic etiology of Alzheimer's disease.

Hoogmartens, Julie; Hens, Elisabeth; Engelborghs, Sebastiaan; De Deyn, Peter Paul; van der Zee, Julie; Van Broeckhoven, Christine; Cacace, Rita

Hoogmartens, Julie; Hens, Elisabeth; Engelborghs, Sebastiaan; De Deyn, Peter Paul; van der Zee, Julie; Van Broeckhoven, Christine; Cacace, Rita.

Afiliação

Hoogmartens J; Neurodegenerative Brain Diseases Group, VIB Center for Molecular Neurology, Antwerp, Belgium; Institute Born-Bunge, Antwerp, Belgium; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Hens E; Institute Born-Bunge, Antwerp, Belgium; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium; Department of Neurology and Memory Clinic, Hospital Network Antwerp, Middelheim and Hoge Beuken, Antwerp, Belgium; Department of Neurology, University Hospital Antwerp, Edegem, Belgium
Engelborghs S; Institute Born-Bunge, Antwerp, Belgium; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium; Department of Neurology, UZ Brussel and Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium.
De Deyn PP; Institute Born-Bunge, Antwerp, Belgium; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium; Department of Neurology and Memory Clinic, Hospital Network Antwerp, Middelheim and Hoge Beuken, Antwerp, Belgium.
van der Zee J; Neurodegenerative Brain Diseases Group, VIB Center for Molecular Neurology, Antwerp, Belgium; Institute Born-Bunge, Antwerp, Belgium; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Van Broeckhoven C; Neurodegenerative Brain Diseases Group, VIB Center for Molecular Neurology, Antwerp, Belgium; Institute Born-Bunge, Antwerp, Belgium; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium. Electronic address: christine.vanbroeckhoven@uantwerpen.vib.be.
Cacace R; Neurodegenerative Brain Diseases Group, VIB Center for Molecular Neurology, Antwerp, Belgium; Institute Born-Bunge, Antwerp, Belgium; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium. Electronic address: rita.cacace@uantwerpen.vib.be.

Neurobiol Aging ; 104: 105.e1-105.e6, 2021 08.

Article em En | MEDLINE | ID: mdl-33892965

Assuntos

Doença de Alzheimer/genética; Metaloproteinase 13 da Matriz/fisiologia; Adulto; Idoso; Idoso de 80 Anos ou mais; Secretases da Proteína Precursora do Amiloide/metabolismo; Ácido Aspártico Endopeptidases/metabolismo; Feminino; Estudos de Associação Genética; Humanos; Masculino; Metaloproteinase 13 da Matriz/genética; Pessoa de Meia-Idade; Mutação de Sentido Incorreto

Palavras-chave

AD; Alzheimer's disease; MMP13; Matrix metalloproteinases; Rare missense mutations

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Metaloproteinase 13 da Matriz / Doença de Alzheimer Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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