Your browser doesn't support javascript.
loading
Cyano Derivatives of 7-Aminoquinoline That Are Highly Emissive in Water: Potential for Sensing Applications.
Chang, Kai-Hsin; Chao, Wei-Chih; Yang, Yu-Hsuan; Wu, Cheng-Ham; Li, Zhi-Bin; Chen, Hung-Che; Chou, Yi-Te; Annie Ho, Ja-An; Li, Xin-Cheng; Peng, Yu-Chiang; Liao, Yu-Chan; Liu, Kuan-Miao; Chao, Chi-Min; Chou, Pi-Tai.
Afiliação
  • Chang KH; Department of Chemistry, National Taiwan University, Taipei, 10617, Taiwan, R.O.C.
  • Chao WC; Department of Chemistry, National Taiwan University, Taipei, 10617, Taiwan, R.O.C.
  • Yang YH; Department of Chemistry, National Taiwan University, Taipei, 10617, Taiwan, R.O.C.
  • Wu CH; Department of Medical Applied Chemistry, Chung Shan Medical University, Taichung, 40201, Taiwan, R.O.C.
  • Li ZB; Department of Medical Education, Chung Shan Medical University Hospital, Taichung, 40201, Taiwan, R.O.C.
  • Chen HC; Department of Chemistry, National Taiwan University, Taipei, 10617, Taiwan, R.O.C.
  • Chou YT; Department of Medical Applied Chemistry, Chung Shan Medical University, Taichung, 40201, Taiwan, R.O.C.
  • Annie Ho JA; Department of Medical Education, Chung Shan Medical University Hospital, Taichung, 40201, Taiwan, R.O.C.
  • Li XC; Department of Medical Applied Chemistry, Chung Shan Medical University, Taichung, 40201, Taiwan, R.O.C.
  • Peng YC; Department of Medical Education, Chung Shan Medical University Hospital, Taichung, 40201, Taiwan, R.O.C.
  • Liao YC; BioAnalytical Chemistry and Nanobiomedicine Laboratory, Department of Biochemical Science and Technology, National Taiwan University, Taipei, 10617, Taiwan, R.O.C.
  • Liu KM; BioAnalytical Chemistry and Nanobiomedicine Laboratory, Department of Biochemical Science and Technology, National Taiwan University, Taipei, 10617, Taiwan, R.O.C.
  • Chao CM; Department of Chemistry, National Taiwan University, Taipei, 10617, Taiwan, R.O.C.
  • Chou PT; Center for Emerging Materials and Advanced Devices, National Taiwan University, Taipei, 10617, Taiwan, R.O.C.
Chemistry ; 27(30): 8040-8047, 2021 May 26.
Article em En | MEDLINE | ID: mdl-33904607
ABSTRACT
6-Cyano-7-aminoquinoline (6CN-7AQ) and 3-cyano-7-aminoquinoline (3CN-7AQ) were synthesized and found to exhibit intense emission with quantum yield as high as 63 % and 85 %, respectively, in water. Conversely, their derivatives 6-cyano-7-azidoquinoline (6CN-7N3 Q) and 3-cyano-7-azidoquinoline (3CN-7N3 Q) show virtually no emission, which makes them suitable to be used as recognition agents in azide reactions based on fluorescence recovery. Moreover, conjugation of 6CN-7AQ with a hydrophobic biomembrane-penetration peptide PFVYLI renders a nearly non-emissive 6CN-7AQ-PFVYLI composite, which can be digested by proteinase K, recovering the highly emissive 6CN-7AQ with ∼200-fold enhancement. The result provides an effective early confirmation for RT-qPCR in viral detection.
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article