Severe infection including disseminated herpes zoster triggered by subclinical Cushing's disease: a case report.
BMC Endocr Disord
; 21(1): 84, 2021 Apr 27.
Article
em En
| MEDLINE
| ID: mdl-33906651
ABSTRACT
BACKGROUND:
Subclinical Cushing's disease (SCD) is defined by corticotroph adenoma-induced mild hypercortisolism without typical physical features of Cushing's disease. Infection is an important complication associated with mortality in Cushing's disease, while no reports on infection in SCD are available. To make clinicians aware of the risk of infection in SCD, we report a case of SCD with disseminated herpes zoster (DHZ) with the mortal outcome. CASE PRESENTATION An 83-year-old Japanese woman was diagnosed with SCD, treated with cabergoline in the outpatient. She was hospitalized for acute pyelonephritis, and her fever gradually resolved with antibiotics. However, herpes zoster appeared on her chest, and the eruptions rapidly spread over the body. She suddenly went into cardiopulmonary arrest and died. Autopsy demonstrated adrenocorticotropic hormone-positive pituitary adenoma, renal abscess, and DHZ.CONCLUSIONS:
As immunosuppression caused by SCD may be one of the triggers of severe infection, the patients with SCD should be assessed not only for the metabolic but also for the immunodeficient status.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hipersecreção Hipofisária de ACTH
/
Herpes Zoster
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
Limite:
Aged80
/
Female
/
Humans
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article