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Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis.
Molloy, Síle F; Ross, Brad; Kanyama, Cecilia; Mfinanga, Sayoki; Lesikari, Sokoine; Heyderman, Robert S; Kalata, Newton; Ellis, Jayne; Kouanfack, Charles; Chanda, Duncan; Temfack, Elvis; Lakhi, Shabir; Moodley, Anand; Chan, Adrienne K; van Oosterhout, Joep J; Mapoure, Yacouba; Mwaba, Peter; Lalloo, David G; Wang, Duolao; Lortholary, Olivier; Jaffar, Shabbar; Hosseinipour, Mina C; Loyse, Angela; Harrison, Thomas S; Bicanic, Tihana.
Afiliação
  • Molloy SF; Centre for Global Health, Institute of Infection and Immunity, St George's University of London, London, United Kingdom.
  • Ross B; Clinical Academic Group in Infection, St George's University Hospital, LondonUnited Kingdom.
  • Kanyama C; Centre for Global Health, Institute of Infection and Immunity, St George's University of London, London, United Kingdom.
  • Mfinanga S; UNC Project, Kamuzu Central Hospital, Lilongwe, Malawi.
  • Lesikari S; National Institute for Medical Research, Muhimbili Centre, Dar es Salaam, Tanzania.
  • Heyderman RS; Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
  • Kalata N; National Institute for Medical Research, Muhimbili Centre, Dar es Salaam, Tanzania.
  • Ellis J; University College London, London, United Kingdom.
  • Kouanfack C; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
  • Chanda D; College of Medicine, Queen Elizabeth Hospital, Blantyre, Malawi.
  • Temfack E; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
  • Lakhi S; College of Medicine, Queen Elizabeth Hospital, Blantyre, Malawi.
  • Moodley A; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
  • Chan AK; College of Medicine, Queen Elizabeth Hospital, Blantyre, Malawi.
  • van Oosterhout JJ; The Hospital for Tropical Diseases, University College Hospital, LondonUnited Kingdom.
  • Mapoure Y; Hȏpital Central Yaoundé/Site ANRS Cameroun, Yaoundé, Cameroon.
  • Mwaba P; Institute for Medical Research and Training, University Teaching Hospital, Lusaka, Zambia.
  • Lalloo DG; Douala General Hospital, Douala, Cameroon.
  • Wang D; National Public Health Laboratory, Yaounde, Cameroon.
  • Lortholary O; University Teaching Hospital, Lusaka, Zambia.
  • Jaffar S; Department of Neurology, University of the Free State, Bloemfontein, South Africa.
  • Hosseinipour MC; Dignitas International, Zomba Central Hospital, Zomba, Malawi.
  • Loyse A; Division of Infectious Diseases, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.
  • Harrison TS; Partners in Hope, LilongweMalawi.
  • Bicanic T; David Geffen School of Medicine, University of California, Los Angeles, USA.
Open Forum Infect Dis ; 8(4): ofab066, 2021 Apr.
Article em En | MEDLINE | ID: mdl-33937434
ABSTRACT
Among 472 patients with human immunodeficiency virus-associated cryptococcal meningitis, 16% had severe visual loss at presentation, and 46% of these were 4-week survivors and remained severely impaired. Baseline cerebrospinal fluid opening pressure ≥40 cmH2O (adjusted odds ratio [aOR], 2.56; 95% confidence interval [CI], 1.36-4.83; P = .02) and fungal burden >6.0 log10 colonies/mL (aOR, 3.01; 95% CI, 1.58-5.7; P = .003) were independently associated with severe visual loss.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article