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Long-term wireless streaming of neural recordings for circuit discovery and adaptive stimulation in individuals with Parkinson's disease.
Gilron, Ro'ee; Little, Simon; Perrone, Randy; Wilt, Robert; de Hemptinne, Coralie; Yaroshinsky, Maria S; Racine, Caroline A; Wang, Sarah S; Ostrem, Jill L; Larson, Paul S; Wang, Doris D; Galifianakis, Nick B; Bledsoe, Ian O; San Luciano, Marta; Dawes, Heather E; Worrell, Gregory A; Kremen, Vaclav; Borton, David A; Denison, Timothy; Starr, Philip A.
Afiliação
  • Gilron R; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA. roee.gilron@ucsf.edu.
  • Little S; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
  • Perrone R; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
  • Wilt R; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
  • de Hemptinne C; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
  • Yaroshinsky MS; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
  • Racine CA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
  • Wang SS; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
  • Ostrem JL; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
  • Larson PS; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
  • Wang DD; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
  • Galifianakis NB; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
  • Bledsoe IO; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
  • San Luciano M; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
  • Dawes HE; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
  • Worrell GA; Mayo Systems Electrophysiology Laboratory, Department of Neurology, Mayo Clinic, Rochester, MN, USA.
  • Kremen V; Mayo Systems Electrophysiology Laboratory, Department of Neurology, Mayo Clinic, Rochester, MN, USA.
  • Borton DA; School of Engineering and Carney Institute, Brown University, Providence, RI, USA.
  • Denison T; Department of Engineering Science, University of Oxford and MRC Brain Network Dynamics Unit, Oxford, UK.
  • Starr PA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Nat Biotechnol ; 39(9): 1078-1085, 2021 09.
Article em En | MEDLINE | ID: mdl-33941932
ABSTRACT
Neural recordings using invasive devices in humans can elucidate the circuits underlying brain disorders, but have so far been limited to short recordings from externalized brain leads in a hospital setting or from implanted sensing devices that provide only intermittent, brief streaming of time series data. Here, we report the use of an implantable two-way neural interface for wireless, multichannel streaming of field potentials in five individuals with Parkinson's disease (PD) for up to 15 months after implantation. Bilateral four-channel motor cortex and basal ganglia field potentials streamed at home for over 2,600 h were paired with behavioral data from wearable monitors for the neural decoding of states of inadequate or excessive movement. We validated individual-specific neurophysiological biomarkers during normal daily activities and used those patterns for adaptive deep brain stimulation (DBS). This technological approach may be widely applicable to brain disorders treatable by invasive neuromodulation.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Adaptação Fisiológica / Tecnologia sem Fio / Monitorização Neurofisiológica Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Adaptação Fisiológica / Tecnologia sem Fio / Monitorização Neurofisiológica Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article