Chromatin Remodeling in the Brain-a NuRDevelopmental Odyssey.
Int J Mol Sci
; 22(9)2021 Apr 30.
Article
em En
| MEDLINE
| ID: mdl-33946340
ABSTRACT
During brain development, the genome must be repeatedly reconfigured in order to facilitate neuronal and glial differentiation. A host of chromatin remodeling complexes facilitates this process. At the genetic level, the non-redundancy of these complexes suggests that neurodevelopment may require a lexicon of remodelers with different specificities and activities. Here, we focus on the nucleosome remodeling and deacetylase (NuRD) complex. We review NuRD biochemistry, genetics, and functions in neural progenitors and neurons.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Montagem e Desmontagem da Cromatina
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Complexo Mi-2 de Remodelação de Nucleossomo e Desacetilase
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article