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Discovery of thieno[2,3-d]pyrimidine-based derivatives as potent VEGFR-2 kinase inhibitors and anti-cancer agents.
El-Metwally, Souad A; Abou-El-Regal, Mohsen M; Eissa, Ibrahim H; Mehany, Ahmed B M; Mahdy, Hazem A; Elkady, Hazem; Elwan, Alaa; Elkaeed, Eslam B.
Afiliação
  • El-Metwally SA; Department of Basic Science, Higher Technological Institute, 10th of Ramadan City 228, Egypt.
  • Abou-El-Regal MM; Department of Chemistry, Faculty of Science, Ain Shams University, Abassia, Cairo 11566, Egypt.
  • Eissa IH; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt. Electronic address: ibrahimeissa@azhar.edu.eg.
  • Mehany ABM; Department of Zoology, Faculty of Science, Al-Azhar University, Cairo 11884, Egypt.
  • Mahdy HA; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.
  • Elkady H; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.
  • Elwan A; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.
  • Elkaeed EB; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Ad Diriyah 13713, Riyadh, Saudi Arabia; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt. Electronic address: eslamkaeed@azhar.edu.eg.
Bioorg Chem ; 112: 104947, 2021 07.
Article em En | MEDLINE | ID: mdl-33964580
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Receptor 2 de Fatores de Crescimento do Endotélio Vascular / Inibidores de Proteínas Quinases / Descoberta de Drogas / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Receptor 2 de Fatores de Crescimento do Endotélio Vascular / Inibidores de Proteínas Quinases / Descoberta de Drogas / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article