<i>LRP1B</i> mutation is associated with tumor HPV status and promotes poor disease outcomes with a higher mutation count in HPV-related cervical carcinoma and head & neck squamous cell carcinoma.

Cao, Can-Hui; Liu, Rang; Lin, Xin-Ran; Luo, Jia-Qi; Cao, Li-Juan; Zhang, Qiu-Ju; Lin, Shou-Ren; Geng, Lan; Sun, Zhong-Yi; Ye, Si-Kang; Yu, Zhi-Ying; Shi, Yu; Xia, Xi

LRP1B mutation is associated with tumor HPV status and promotes poor disease outcomes with a higher mutation count in HPV-related cervical carcinoma and head & neck squamous cell carcinoma.

Cao, Can-Hui; Liu, Rang; Lin, Xin-Ran; Luo, Jia-Qi; Cao, Li-Juan; Zhang, Qiu-Ju; Lin, Shou-Ren; Geng, Lan; Sun, Zhong-Yi; Ye, Si-Kang; Yu, Zhi-Ying; Shi, Yu; Xia, Xi.

Afiliação

Cao CH; Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Guangdong, 518036, China.
Liu R; Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Guangdong, 518036, China.
Lin XR; Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Guangdong, 518036, China.
Luo JQ; Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Guangdong, 518036, China.
Cao LJ; Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Guangdong, 518036, China.
Zhang QJ; Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Guangdong, 518036, China.
Lin SR; Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Guangdong, 518036, China.
Geng L; Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Guangdong, 518036, China.
Sun ZY; Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Guangdong, 518036, China.
Ye SK; Department of Critical Care Medicine, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Yu ZY; Department of Gynecology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China.
Shi Y; Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Guangdong, 518036, China.
Xia X; Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Guangdong, 518036, China.

Int J Biol Sci ; 17(7): 1744-1756, 2021.

Article em En | MEDLINE | ID: mdl-33994859

Assuntos

Neoplasias de Cabeça e Pescoço/genética; Mutação; Papillomaviridae; Infecções por Papillomavirus/genética; Receptores de LDL/genética; Carcinoma de Células Escamosas de Cabeça e Pescoço/genética; Neoplasias do Colo do Útero/genética; Biomarcadores Tumorais/genética; Biomarcadores Tumorais/metabolismo; Variações do Número de Cópias de DNA; Análise Mutacional de DNA; DNA de Neoplasias/genética; DNA de Neoplasias/metabolismo; Feminino; Perfilação da Expressão Gênica; Neoplasias de Cabeça e Pescoço/metabolismo; Neoplasias de Cabeça e Pescoço/patologia; Humanos; Pessoa de Meia-Idade; Infecções por Papillomavirus/metabolismo; Infecções por Papillomavirus/patologia; Receptores de LDL/metabolismo; Carcinoma de Células Escamosas de Cabeça e Pescoço/metabolismo; Carcinoma de Células Escamosas de Cabeça e Pescoço/patologia; Neoplasias do Colo do Útero/metabolismo; Neoplasias do Colo do Útero/patologia

Palavras-chave

LRP1B mutation; cervical carcinoma; head and neck squamous cell carcinoma; tumor HPV status; tumor mutation count

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Papillomaviridae / Receptores de LDL / Neoplasias do Colo do Útero / Infecções por Papillomavirus / Carcinoma de Células Escamosas de Cabeça e Pescoço / Neoplasias de Cabeça e Pescoço / Mutação Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google