Novel and Highly Potent ATR Inhibitor M4344 Kills Cancer Cells With Replication Stress, and Enhances the Chemotherapeutic Activity of Widely Used DNA Damaging Agents.

Jo, Ukhyun; Senatorov, Ilya S; Zimmermann, Astrid; Saha, Liton Kumar; Murai, Yasuhisa; Kim, Se Hyun; Rajapakse, Vinodh N; Elloumi, Fathi; Takahashi, Nobuyuki; Schultz, Christopher W; Thomas, Anish; Zenke, Frank T; Pommier, Yves

Jo, Ukhyun; Senatorov, Ilya S; Zimmermann, Astrid; Saha, Liton Kumar; Murai, Yasuhisa; Kim, Se Hyun; Rajapakse, Vinodh N; Elloumi, Fathi; Takahashi, Nobuyuki; Schultz, Christopher W; Thomas, Anish; Zenke, Frank T; Pommier, Yves.

Afiliação

Jo U; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, Bethesda, Maryland. ukhyun.jo@nih.gov pommier@nih.gov.
Senatorov IS; Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Zimmermann A; Merck KGaA, Biopharma R&D, Translational Innovation Platform Oncology, Darmstadt, Germany.
Saha LK; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, Bethesda, Maryland.
Murai Y; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, Bethesda, Maryland.
Kim SH; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, Bethesda, Maryland.
Rajapakse VN; Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, South Korea.
Elloumi F; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, Bethesda, Maryland.
Takahashi N; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, Bethesda, Maryland.
Schultz CW; General Dynamics Information Technology Inc., Fairfax, Virginia.
Thomas A; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, Bethesda, Maryland.
Zenke FT; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, Bethesda, Maryland.
Pommier Y; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, Bethesda, Maryland.

Mol Cancer Ther ; 20(8): 1431-1441, 2021 08.

Article em En | MEDLINE | ID: mdl-34045232

Assuntos

Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia; Proteínas Mutadas de Ataxia Telangiectasia/antagonistas & inibidores; Replicação do DNA; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Neoplasias Pulmonares/tratamento farmacológico; Carcinoma de Pequenas Células do Pulmão/tratamento farmacológico; Animais; Apoptose; Proliferação de Células; Desoxicitidina/administração & dosagem; Desoxicitidina/análogos & derivados; Feminino; Humanos; Irinotecano/administração & dosagem; Isoxazóis/administração & dosagem; Neoplasias Pulmonares/metabolismo; Neoplasias Pulmonares/patologia; Camundongos; Camundongos Nus; Morfolinas/administração & dosagem; Pirazinas/administração & dosagem; Pirazóis/administração & dosagem; Carcinoma de Pequenas Células do Pulmão/metabolismo; Carcinoma de Pequenas Células do Pulmão/patologia; Topotecan/administração & dosagem; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto; Gencitabina

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Regulação Neoplásica da Expressão Gênica / Replicação do DNA / Carcinoma de Pequenas Células do Pulmão / Proteínas Mutadas de Ataxia Telangiectasia / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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