Discovery of new VEGFR-2 inhibitors based on bis([1, 2, 4]triazolo)[4,3-<i>a</i>:3',4'-<i>c</i>]quinoxaline derivatives as anticancer agents and apoptosis inducers.

Alsaif, Nawaf A; Taghour, Mohammed S; Alanazi, Mohammed M; Obaidullah, Ahmad J; Al-Mehizia, Abdulrahman A; Alanazi, Manal M; Aldawas, Saleh; Elwan, Alaa; Elkady, Hazem

Discovery of new VEGFR-2 inhibitors based on bis([1, 2, 4]triazolo)[4,3-a:3',4'-c]quinoxaline derivatives as anticancer agents and apoptosis inducers.

Alsaif, Nawaf A; Taghour, Mohammed S; Alanazi, Mohammed M; Obaidullah, Ahmad J; Al-Mehizia, Abdulrahman A; Alanazi, Manal M; Aldawas, Saleh; Elwan, Alaa; Elkady, Hazem.

Afiliação

Alsaif NA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Taghour MS; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Alanazi MM; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Obaidullah AJ; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Al-Mehizia AA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Alanazi MM; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Aldawas S; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Elwan A; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Elkady H; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.

J Enzyme Inhib Med Chem ; 36(1): 1093-1114, 2021 Dec.

Article em En | MEDLINE | ID: mdl-34056992

Assuntos

Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Descoberta de Drogas; Inibidores de Proteínas Quinases/farmacologia; Quinoxalinas/farmacologia; Receptor 2 de Fatores de Crescimento do Endotélio Vascular/antagonistas & inibidores; Antineoplásicos/síntese química; Antineoplásicos/química; Proliferação de Células/efeitos dos fármacos; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Estrutura Molecular; Inibidores de Proteínas Quinases/síntese química; Inibidores de Proteínas Quinases/química; Quinoxalinas/síntese química; Quinoxalinas/química; Relação Estrutura-Atividade; Receptor 2 de Fatores de Crescimento do Endotélio Vascular/metabolismo

Palavras-chave

Anticancer; VEGFR-2; apoptosis; bis([1,2,4]triazolo)[4,3-a:3',4'-c]quinoxaline; molecular docking

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinoxalinas / Apoptose / Receptor 2 de Fatores de Crescimento do Endotélio Vascular / Inibidores de Proteínas Quinases / Descoberta de Drogas / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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