Treatment with a GSK-3ß/HDAC Dual Inhibitor Restores Neuronal Survival and Maturation in an In Vitro and In Vivo Model of <i>CDKL5</i> Deficiency Disorder.

Loi, Manuela; Gennaccaro, Laura; Fuchs, Claudia; Trazzi, Stefania; Medici, Giorgio; Galvani, Giuseppe; Mottolese, Nicola; Tassinari, Marianna; Giorgini, Roberto Rimondini; Milelli, Andrea; Ciani, Elisabetta

Treatment with a GSK-3ß/HDAC Dual Inhibitor Restores Neuronal Survival and Maturation in an In Vitro and In Vivo Model of CDKL5 Deficiency Disorder.

Loi, Manuela; Gennaccaro, Laura; Fuchs, Claudia; Trazzi, Stefania; Medici, Giorgio; Galvani, Giuseppe; Mottolese, Nicola; Tassinari, Marianna; Giorgini, Roberto Rimondini; Milelli, Andrea; Ciani, Elisabetta.

Afiliação

Loi M; Department of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy.
Gennaccaro L; Department of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy.
Fuchs C; Department of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy.
Trazzi S; Department of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy.
Medici G; Department of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy.
Galvani G; Department of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy.
Mottolese N; Department of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy.
Tassinari M; Department of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy.
Giorgini RR; Department of Medical and Clinical Sciences, University of Bologna, 40126 Bologna, Italy.
Milelli A; Department for Life Quality Studies, University of Bologna, 47921 Rimini, Italy.
Ciani E; Department of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy.

Int J Mol Sci ; 22(11)2021 May 31.

Article em En | MEDLINE | ID: mdl-34073043

Assuntos

Sobrevivência Celular/efeitos dos fármacos; Síndromes Epilépticas/tratamento farmacológico; Glicogênio Sintase Quinase 3 beta/antagonistas & inibidores; Inibidores de Histona Desacetilases; Neurônios/efeitos dos fármacos; Espasmos Infantis/tratamento farmacológico; Animais; Linhagem Celular; Hipocampo/efeitos dos fármacos; Hipocampo/patologia; Inibidores de Histona Desacetilases/farmacologia; Inibidores de Histona Desacetilases/uso terapêutico; Humanos; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Neurônios/patologia

Palavras-chave

CDKL5 deficiency disorder; GSK-3ß; HDAC6; dual inhibitor; hippocampal defects; neuronal survival; synapse development

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Espasmos Infantis / Sobrevivência Celular / Inibidores de Histona Desacetilases / Glicogênio Sintase Quinase 3 beta / Síndromes Epilépticas / Neurônios Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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