Ultrasound halo sign as a potential monitoring tool for patients with giant cell arteritis: a prospective analysis.
Ann Rheum Dis
; 80(11): 1475-1482, 2021 11.
Article
em En
| MEDLINE
| ID: mdl-34215646
ABSTRACT
OBJECTIVES:
To assess the sensitivity to change of ultrasound halo features and their association with disease activity and glucocorticoid (GC) treatment in patients with newly diagnosed giant cell arteritis (GCA).METHODS:
Prospective study of patients with ultrasound-confirmed GCA who underwent serial ultrasound assessments of the temporal artery (TA) and axillary artery (AX) at fixed time points. The number of segments with halo and maximum halo intima-media thickness (IMT) was recorded. Time points in which >80% of patients were assessed were considered for analysis. Halo features at disease presentation and first relapse were compared.RESULTS:
49 patients were assessed at 354 visits. Halo sensitivity to change was assessed at weeks 1, 3, 6, 12 and 24 and showed a significant standardised mean difference between all time points and baseline for the TA halo features but only after week 6 for the AX halo features. The number of TA segments with halo and sum and maximum TA halo IMT showed a significant correlation with erythrocyte sedimentation rate (0.41, 0.44 and 0.48), C reactive protein (0.34, 0.39 and 0.41), Birmingham Vasculitis Activity Score (0.29, 0.36 and 0.35) and GC cumulative dose (-0.34, -0.37 and -0.32); no significant correlation was found for the AX halo features. Halo sign was present in 94% of first disease relapses but with a lower mean number of segments with halo and sum of halo IMT compared with disease onset (2.93±1.59 mm vs 4.85±1.51 mm, p=0.0012; 2.01±1.13 mm vs 4.49±1.95 mm, p=0.0012).CONCLUSIONS:
Ultrasound is a useful imaging tool to assess disease activity and response to treatment in patients with GCA.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Artéria Axilar
/
Artérias Temporais
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Arterite de Células Gigantes
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Túnica Íntima
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
Limite:
Aged
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Aged80
/
Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article