[Acyclic analogs of ribavirin. Synthesis and antiviral activity]. / Atsiklicheskie analogi ribavirina. Sintez i protivovirusnaia aktivnost'.
Bioorg Khim
; 14(5): 689-93, 1988 May.
Article
em Ru
| MEDLINE
| ID: mdl-3422011
ABSTRACT
Activity of several ribavirin analogues, viz.1-(2-hydroxyethoxymethyl)-, 1-(3-hydroxypropoxymethyl)-, 1-(4-hydroxybutoxymethyl)- and 1-(2,3-dihydroxypropyl)-1,2,4-triazole 5- and 3-carboxamides, against human adenovirus type 2 in the Hep-2 cell culture has been studied. The ether oxygen atom imitating the ribose O4' was shown to be essential for the antiviral activity. 1-(2-Hydroxyethoxymethyl)-1,2,4-triazole 3-carboxamide, a structural analogue of ribavirin in which the hydroxyl group is apparently equivalent to the ribose 5'-OH, possesses the highest activity among the compounds studied. Lengthening of the alkyl side chain reduces essentially the antiviral activity.
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Ribavirina
/
Ribonucleosídeos
Limite:
Humans
Idioma:
Ru
Ano de publicação:
1988
Tipo de documento:
Article