Antimalarial Activities of (Z)-2-(Nitroheteroarylmethylene)-3(2H)-Benzofuranone Derivatives: In Vitro and In Vivo Assessment and ß-Hematin Formation Inhibition Activity.

Navidpour, Latifeh; Chibale, Kelly; Esmaeili, Somayeh; Ghiaee, Azadeh; Hadj-Esfandiari, Narges; Irani, Mahboubeh; Ahmadi Koulaei, Sheyda; Yassa, Narguess

Antimalarial Activities of (Z)-2-(Nitroheteroarylmethylene)-3(2H)-Benzofuranone Derivatives: In Vitro and In Vivo Assessment and ß-Hematin Formation Inhibition Activity.

Navidpour, Latifeh; Chibale, Kelly; Esmaeili, Somayeh; Ghiaee, Azadeh; Hadj-Esfandiari, Narges; Irani, Mahboubeh; Ahmadi Koulaei, Sheyda; Yassa, Narguess.

Afiliação

Navidpour L; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Chibale K; South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry, University of Cape Town, Rondebosch, South Africa.
Esmaeili S; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch, South Africa.
Ghiaee A; School of Traditional Medicine, Traditional Medicine & Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hadj-Esfandiari N; School of Traditional Medicine, Traditional Medicine & Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Irani M; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Ahmadi Koulaei S; School of Traditional Medicine, Traditional Medicine & Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Yassa N; Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Antimicrob Agents Chemother ; 65(9): e0268320, 2021 08 17.

Article em En | MEDLINE | ID: mdl-34228544

Assuntos

Antimaláricos; Hemeproteínas; Antimaláricos/farmacologia; Cloroquina; Humanos; Plasmodium falciparum

Palavras-chave

antimalarial activity; antiplasmodial activity; benzofuranone; in vivo; nitrofuran; nitroimidazole; nitrothiophene; ß-hematin formation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hemeproteínas / Antimaláricos Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hemeproteínas / Antimaláricos Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article