Neuroprotective effect of newly synthesized 4-aminopyridine derivatives on cuprizone-induced demyelination in mice-a behavioral and immunohistochemical study.

Kostadinova, Ivanka; Landzhov, Boycho; Marinov, Lyubomir; Vezenkov, Lyubomir; Danchev, Nikolai

Kostadinova, Ivanka; Landzhov, Boycho; Marinov, Lyubomir; Vezenkov, Lyubomir; Danchev, Nikolai.

Afiliação

Kostadinova I; Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Str., 1000, Sofia, Bulgaria. i.kostadinova@pharmfac.mu-sofia.bg.
Landzhov B; Department of Anatomy, Histology and Embryology, Faculty of Medicine, Medical University of Sofia, 2 Zdrave Str., 1431, Sofia, Bulgaria.
Marinov L; Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Str., 1000, Sofia, Bulgaria.
Vezenkov L; Department of Organic Chemistry, University of Chemical Technology and Metallurgy, 8 St. Kliment Ohridski Blvd., 1756, Sofia, Bulgaria.
Danchev N; Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Str., 1000, Sofia, Bulgaria.

Amino Acids ; 53(8): 1279-1286, 2021 Aug.

Article em En | MEDLINE | ID: mdl-34240251

Assuntos

4-Aminopiridina/farmacologia; Comportamento Animal/efeitos dos fármacos; Cuprizona/farmacologia; Doenças Desmielinizantes/prevenção & controle; Fármacos Neuroprotetores/farmacologia; Animais; Doenças Desmielinizantes/induzido quimicamente; Imuno-Histoquímica; Masculino; Camundongos

Palavras-chave

4-aminopyridine; Cuprizone; Demyelinating diseases; Memory; Multiple sclerosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Comportamento Animal / 4-Aminopiridina / Doenças Desmielinizantes / Fármacos Neuroprotetores / Cuprizona Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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