Body Mass Index and Risk of COVID-19 Diagnosis, Hospitalization, and Death: A Cohort Study of 2 524 926 Catalans.
J Clin Endocrinol Metab
; 106(12): e5030-e5042, 2021 11 19.
Article
em En
| MEDLINE
| ID: mdl-34297116
ABSTRACT
CONTEXT A comprehensive understanding of the association between body mass index (BMI) and coronavirus disease 2019 (COVID-19) is still lacking. OBJECTIVE:
To investigate associations between BMI and risk of COVID-19 diagnosis, hospitalization with COVID-19, and death after a COVID-19 diagnosis or hospitalization (subsequent death), accounting for potential effect modification by age and sex.DESIGN:
Population-based cohort study.SETTING:
Primary care records covering >80% of the Catalan population, linked to regionwide testing, hospital, and mortality records from March to May 2020.PARTICIPANTS:
Adults (≥18 years) with at least 1 measurement of weight and height. MAIN OUTCOMEMEASURES:
Hazard ratios (HR) for each outcome.RESULTS:
We included 2 524 926 participants. After 67 days of follow-up, 57 443 individuals were diagnosed with COVID-19, 10 862 were hospitalized with COVID-19, and 2467 had a subsequent death. BMI was positively associated with being diagnosed and hospitalized with COVID-19. Compared to a BMI of 22 kg/m2, the HR (95% CI) of a BMI of 31 kg/m2 was 1.22 (1.19-1.24) for diagnosis and 1.88 (1.75-2.03) and 2.01 (1.86-2.18) for hospitalization without and with a prior outpatient diagnosis, respectively. The association between BMI and subsequent death was J-shaped, with a modestly higher risk of death among individuals with BMIsâ ≤â 19 kg/m2 and a more pronounced increasing risk for BMIsâ ≥â 40 kg/m2. The increase in risk for COVID-19 outcomes was particularly pronounced among younger patients.CONCLUSIONS:
There is a monotonic association between BMI and COVID-19 diagnosis and hospitalization risks but a J-shaped relationship with mortality. More research is needed to unravel the mechanisms underlying these relationships.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Índice de Massa Corporal
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COVID-19
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Hospitalização
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
/
Incidence_studies
/
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article