Mediterranean and Western diet effects on Alzheimer's disease biomarkers, cerebral perfusion, and cognition in mid-life: A randomized trial.
Alzheimers Dement
; 18(3): 457-468, 2022 03.
Article
em En
| MEDLINE
| ID: mdl-34310044
ABSTRACT
INTRODUCTION:
Mid-life dietary patterns are associated with Alzheimer's disease (AD) risk, although few controlled trials have been conducted.METHODS:
Eighty-seven participants (age range 45 to 65) with normal cognition (NC, n = 56) or mild cognitive impairment (MCI, n = 31) received isocaloric diets high or low in saturated fat, glycemic index, and sodium (Western-like/West-diet vs. Mediterranean-like/Med-diet) for 4 weeks. Diet effects on cerebrospinal fluid (CSF) biomarkers, cognition, and cerebral perfusion were assessed to determine whether responses differed by cognitive status.RESULTS:
CSF amyloid beta (Aß)42/40 ratios increased following the Med-diet, and decreased after West-diet for NC adults, whereas the MCI group showed the reverse pattern. For the MCI group, the West-diet reduced and the Med-diet increased total tau (t-tau), whereas CSF Aß42 /t-tau ratios increased following the West-diet and decreased following the Med-diet. For NC participants, the Med-diet increased and the West-diet decreased cerebral perfusion.DISCUSSION:
Diet response during middle age may highlight early pathophysiological processes that increase AD risk.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Dieta Mediterrânea
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Doença de Alzheimer
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Disfunção Cognitiva
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Dieta Ocidental
Tipo de estudo:
Clinical_trials
Limite:
Adult
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Aged
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Humans
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Middle aged
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article