Novel Humanized Mesothelin-Expressing Genetically Engineered Mouse Models Underscore Challenges in Delivery of Complex Therapeutics to Pancreatic Cancers.

Hagerty, Brendan; O'Sullivan, T Norene; Zhang, Xianyu; Collins, N Keith; Custer Lawrence, Wendi; Bassel, Laura L; Pate, Nathan; Xu, Jian; Guerin, Theresa M; Kozlov, Serguei; Alewine, Christine

Hagerty, Brendan; O'Sullivan, T Norene; Zhang, Xianyu; Collins, N Keith; Custer Lawrence, Wendi; Bassel, Laura L; Pate, Nathan; Xu, Jian; Guerin, Theresa M; Kozlov, Serguei; Alewine, Christine.

Afiliação

Hagerty B; Laboratory of Molecular Biology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.
O'Sullivan TN; Surgical Oncology Program, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.
Zhang X; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland.
Collins NK; Laboratory of Molecular Biology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.
Custer Lawrence W; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland.
Bassel LL; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland.
Pate N; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland.
Xu J; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland.
Guerin TM; Laboratory of Molecular Biology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.
Kozlov S; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland.
Alewine C; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland. alewinecc@mail.nih.gov christine.alewine@nih.gov kozlovse@nci.gov.

Mol Cancer Ther ; 20(10): 2082-2092, 2021 10.

Article em En | MEDLINE | ID: mdl-34315768

Assuntos

Adenocarcinoma/terapia; Mesotelina/administração & dosagem; Mesotelioma/terapia; Neoplasias Pancreáticas/terapia; Adenocarcinoma/genética; Adenocarcinoma/patologia; Animais; Apoptose; Proliferação de Células; Feminino; Engenharia Genética; Humanos; Masculino; Mesotelina/genética; Mesotelina/metabolismo; Mesotelioma/genética; Mesotelioma/patologia; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Neoplasias Pancreáticas/genética; Neoplasias Pancreáticas/patologia; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Adenocarcinoma / Mesotelina / Mesotelioma Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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