Identification of pimavanserin tartrate as a potent Ca<sup>2+</sup>-calcineurin-NFAT pathway inhibitor for glioblastoma therapy.

Liu, Zhen-Zhen; Liu, Xiao-Ning; Fan, Rui-Cheng; Jia, Yu-Ping; Zhang, Qing-Ke; Gao, Xin-Qing; Wang, Yu-Qing; Yang, Meng-Qing; Ji, Li-Zhen; Zhou, Yong-Qing; Li, Hong-Li; Li, Ping; Tang, Bo

Identification of pimavanserin tartrate as a potent Ca²⁺-calcineurin-NFAT pathway inhibitor for glioblastoma therapy.

Liu, Zhen-Zhen; Liu, Xiao-Ning; Fan, Rui-Cheng; Jia, Yu-Ping; Zhang, Qing-Ke; Gao, Xin-Qing; Wang, Yu-Qing; Yang, Meng-Qing; Ji, Li-Zhen; Zhou, Yong-Qing; Li, Hong-Li; Li, Ping; Tang, Bo.

Afiliação

Liu ZZ; College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institutes of Biomedical Sciences, Shandong Normal Universi
Liu XN; College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institutes of Biomedical Sciences, Shandong Normal Universi
Fan RC; Department of Histology and Embryology, College of Basic Medicine, Army Medical University, Chongqing, 400038, China.
Jia YP; Shandong Academy of Pharmaceutical Sciences, Jinan, 250014, China.
Zhang QK; School of Information Science and Engineering, Shandong Normal University, Jinan, 250101, China.
Gao XQ; College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institutes of Biomedical Sciences, Shandong Normal Universi
Wang YQ; College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institutes of Biomedical Sciences, Shandong Normal Universi
Yang MQ; College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institutes of Biomedical Sciences, Shandong Normal Universi
Ji LZ; College of Life Sciences, Shandong Normal University, Jinan, 250014, China.
Zhou YQ; College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institutes of Biomedical Sciences, Shandong Normal Universi
Li HL; Department of Histology and Embryology, College of Basic Medicine, Army Medical University, Chongqing, 400038, China. lihongli@tmmu.edu.cn.
Li P; College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institutes of Biomedical Sciences, Shandong Normal Universi
Tang B; College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institutes of Biomedical Sciences, Shandong Normal Universi

Acta Pharmacol Sin ; 42(11): 1860-1874, 2021 11.

Article em En | MEDLINE | ID: mdl-34363007

Assuntos

Neoplasias Encefálicas/metabolismo; Inibidores de Calcineurina/farmacologia; Sinalização do Cálcio/efeitos dos fármacos; Glioblastoma/metabolismo; Fatores de Transcrição NFATC/metabolismo; Piperidinas/farmacologia; Ureia/análogos & derivados; Animais; Neoplasias Encefálicas/tratamento farmacológico; Calcineurina/metabolismo; Inibidores de Calcineurina/uso terapêutico; Sinalização do Cálcio/fisiologia; Proteínas de Ligação ao Cálcio/antagonistas & inibidores; Proteínas de Ligação ao Cálcio/metabolismo; Linhagem Celular Tumoral; Movimento Celular/efeitos dos fármacos; Movimento Celular/fisiologia; Relação Dose-Resposta a Droga; Feminino; Glioblastoma/tratamento farmacológico; Células HeLa; Humanos; Masculino; Proteínas de Membrana/antagonistas & inibidores; Proteínas de Membrana/metabolismo; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Fatores de Transcrição NFATC/antagonistas & inibidores; Piperidinas/uso terapêutico; Ureia/farmacologia; Ureia/uso terapêutico; Ensaios Antitumorais Modelo de Xenoenxerto/métodos

Palavras-chave

NFAT signaling pathway; SOCE; drug repurposing; glioblastoma; pimavanserin tartrate

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Ureia / Neoplasias Encefálicas / Glioblastoma / Sinalização do Cálcio / Fatores de Transcrição NFATC / Inibidores de Calcineurina Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google