Electrochemical borylation of carboxylic acids.
Proc Natl Acad Sci U S A
; 118(34)2021 08 24.
Article
em En
| MEDLINE
| ID: mdl-34404720
ABSTRACT
A simple electrochemically mediated method for the conversion of alkyl carboxylic acids to their borylated congeners is presented. This protocol features an undivided cell setup with inexpensive carbon-based electrodes and exhibits a broad substrate scope and scalability in both flow and batch reactors. The use of this method in challenging contexts is exemplified with a modular formal synthesis of jawsamycin, a natural product harboring five cyclopropane rings.
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Base de dados:
MEDLINE
Assunto principal:
Ácidos Borônicos
/
Ácidos Carboxílicos
/
Eletrodos
/
Técnicas Eletroquímicas
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article