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Allulose in human diet: the knowns and the unknowns.
Daniel, Hannelore; Hauner, Hans; Hornef, Mathias; Clavel, Thomas.
Afiliação
  • Daniel H; ex. School of Life Sciences, Technical University of Munich, Gregor-Mendel-Strasse 2, 85354Freising, Germany.
  • Hauner H; Institute of Nutritional Medicine, School of Medicine and Else Kroener-Fresenius-Centre of Nutritional Medicine, School of Life Sciences, Technical University of Munich, Gregor-Mendel-Strasse 2, 85354Freising, Germany.
  • Hornef M; Institute of Medical Microbiology, University Hospital of RWTH Aachen, Pauwelsstraße 30, D-52074Aachen, Germany.
  • Clavel T; Institute of Medical Microbiology, Functional Microbiome Research Group University Hospital of RWTH Aachen, Pauwelsstraße 30, D-52074Aachen, Germany.
Br J Nutr ; 128(2): 172-178, 2022 07 28.
Article em En | MEDLINE | ID: mdl-34409930
ABSTRACT
D-Allulose, also referred to as psicose, is a C3-epimer of D-fructose used as a sugar substitute in low energy products. It can be formed naturally during processing of food and drinks containing sucrose and fructose or is prepared by chemical synthesis or via enzymatic treatment with epimerases from fructose. Estimated intakes via Western style diets including sweetened beverages are below 500 mg per d but, when used as a sugar replacement, intake may reach 10 to 30 g per d depending on the food consumed. Due to its structural similarity with fructose, allulose uses the same transport and distribution pathways. But in contrast to fructose, the human genome does not encode for enzymes that are able to metabolise allulose leading to an almost complete renal excretion of the absorbed dose and near-to-zero energetic yield. However, in vitro studies have shown that certain bacteria such as Klebsiella pneumonia are able to utilise allulose as a substrate. This finding has been a subject of concern, since Klebsiella pneumoniae represents an opportunistic human pathogen. It therefore raised the question of whether a high dietary intake of allulose may cause an undesirable growth advantage for potentially harmful bacteria at mucosal sites such as the intestine or at systemic sites following invasive infection. In this brief review, we discuss the current state of science on these issues and define the research needs to better understand the fate of allulose and its metabolic and microbiological effects when ingested as a sugar substitute.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Edulcorantes / Frutose Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Edulcorantes / Frutose Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article