Improving Dissolution Behavior and Oral Absorption of Drugs with pH-Dependent Solubility Using pH Modifiers: A Physiologically Realistic Mass Transport Analysis.

Salehi, Niloufar; Kuminek, Gislaine; Al-Gousous, Jozef; Sperry, David C; Greenwood, Dale E; Waltz, Nicholas M; Amidon, Gordon L; Ziff, Robert M; Amidon, Gregory E

Salehi, Niloufar; Kuminek, Gislaine; Al-Gousous, Jozef; Sperry, David C; Greenwood, Dale E; Waltz, Nicholas M; Amidon, Gordon L; Ziff, Robert M; Amidon, Gregory E.

Afiliação

Salehi N; Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan 48109, United States.
Kuminek G; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States.
Al-Gousous J; Synthetic Molecule Design & Development, Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
Sperry DC; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States.
Greenwood DE; Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Mainz 55128, Germany.
Waltz NM; Synthetic Molecule Design & Development, Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
Amidon GL; Synthetic Molecule Design & Development, Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
Ziff RM; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States.
Amidon GE; College of Pharmacy, Ohio State University, Columbus, Ohio 43210, United States.

Mol Pharm ; 18(9): 3326-3341, 2021 09 06.

Article em En | MEDLINE | ID: mdl-34428047

Assuntos

Excipientes/farmacologia; Absorção Gastrointestinal/efeitos dos fármacos; Concentração de Íons de Hidrogênio/efeitos dos fármacos; Modelos Biológicos; Administração Oral; Betaína/farmacologia; Disponibilidade Biológica; Química Farmacêutica; Simulação por Computador; Desenho de Fármacos; Liberação Controlada de Fármacos; Fumaratos/farmacologia; Humanos; Solubilidade; Tartaratos/farmacologia

Palavras-chave

H2 antagonists; H2 blockers; achlorhydria; diffusion layer model; dissolution modeling; elevated gastric pH; gastrointestinal simulator; hierarchical mass transfer model; mass transport model; pH modifier; physiological mass transfer model; proton pump inhibitor; surface pH; surface solubility

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Excipientes / Absorção Gastrointestinal / Concentração de Íons de Hidrogênio / Modelos Biológicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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