U-shaped Association Between Dietary Zinc Intake and New-onset Diabetes: A Nationwide Cohort Study in China.
J Clin Endocrinol Metab
; 107(2): e815-e824, 2022 01 18.
Article
em En
| MEDLINE
| ID: mdl-34448874
ABSTRACT
AIMS:
We aimed to investigate the relationship of dietary zinc intake with new-onset diabetes among Chinese adults. MATERIALS ANDMETHODS:
A total of 16 257 participants who were free of diabetes at baseline from the China Health and Nutrition Survey were included. Dietary intake was measured by 3 consecutive 24-hour dietary recalls combined with a household food inventory. Participants with self-reported physician-diagnosed diabetes, or fasting glucoseâ ≥â 7.0 mmol/L, or glycated hemoglobinâ ≥â 6.5% during the follow-up were defined as having new-onset diabetes.RESULTS:
A total of 1097 participants developed new-onset diabetes during a median follow-up duration of 9.0 years. Overall, the association between dietary zinc intake and new-onset diabetes followed a U-shape (P for nonlinearityâ <â 0.001). The risk of new-onset diabetes was significantly lower in participants with zinc intakeâ <â 9.1 mg/day (per mg/day hazard ratio [HR], 0.73; 95% CI, 0.60-0.88), and higher in those with zinc intakeâ ≥â 9.1 mg/day (per mg/day HR, 1.10; 95% CI, 1.07-1.13). Consistently, when dietary zinc intake was assessed as deciles, compared with those in deciles 2-8 (8.9 -<12.2 mg/day), the risk of new-onset diabetes was higher for decile 1 (<8.9 mg/day HR, 1.29; 95% CI, 1.04-1.62), and deciles 9 to 10 (≥12.2 mg/day HR, 1.62; 95% CI, 1.38-1.90). Similar U-shaped relations were found for plant-derived or animal-derived zinc intake with new-onset diabetes (all P for nonlinearityâ <â 0.001).CONCLUSIONS:
There was a U-shaped association between dietary zinc intake and new-onset diabetes in general Chinese adults, with an inflection point at about 9.1 mg/day.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oligoelementos
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Zinco
/
Inquéritos sobre Dietas
/
Diabetes Mellitus
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article