Application of a simple unstructured kinetic and cost of goods models to support T-cell therapy manufacture.

Shariatzadeh, Maryam; Lopes, Adriana G; Glen, Katie E; Sinclair, Andrew; Thomas, Rob J

Shariatzadeh, Maryam; Lopes, Adriana G; Glen, Katie E; Sinclair, Andrew; Thomas, Rob J.

Afiliação

Shariatzadeh M; Centre for Biological Engineering, Wolfson School of Mechanical and Electrical and Manufacturing Engineering, Loughborough University, Epinal Way, Loughborough University, Loughborough, UK.
Lopes AG; Biopharm Services, Chesham, UK.
Glen KE; Centre for Biological Engineering, Wolfson School of Mechanical and Electrical and Manufacturing Engineering, Loughborough University, Epinal Way, Loughborough University, Loughborough, UK.
Sinclair A; Biopharm Services, Chesham, UK.
Thomas RJ; Centre for Biological Engineering, Wolfson School of Mechanical and Electrical and Manufacturing Engineering, Loughborough University, Epinal Way, Loughborough University, Loughborough, UK.

Biotechnol Prog ; 37(6): e3205, 2021 11.

Article em En | MEDLINE | ID: mdl-34455707

Assuntos

Reatores Biológicos; Técnicas de Cultura de Células/métodos; Terapia Baseada em Transplante de Células e Tecidos; Linfócitos T/citologia; Contagem de Células; Proliferação de Células; Células Cultivadas; Custos e Análise de Custo; Humanos; Cinética

Palavras-chave

T-cell processing; cost analysis; modeling framework; process optimization; scalable T-cell manufacturing

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T / Técnicas de Cultura de Células / Reatores Biológicos / Terapia Baseada em Transplante de Células e Tecidos Tipo de estudo: Health_economic_evaluation / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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