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Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy.
Grote Beverborg, Niels; Später, Daniela; Knöll, Ralph; Hidalgo, Alejandro; Yeh, Steve T; Elbeck, Zaher; Silljé, Herman H W; Eijgenraam, Tim R; Siga, Humam; Zurek, Magdalena; Palmér, Malin; Pehrsson, Susanne; Albery, Tamsin; Bomer, Nils; Hoes, Martijn F; Boogerd, Cornelis J; Frisk, Michael; van Rooij, Eva; Damle, Sagar; Louch, William E; Wang, Qing-Dong; Fritsche-Danielson, Regina; Chien, Kenneth R; Hansson, Kenny M; Mullick, Adam E; de Boer, Rudolf A; van der Meer, Peter.
Afiliação
  • Grote Beverborg N; Department of Cardiology University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Später D; Bioscience Cardiovascular, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden. daniela.spaeter@astrazeneca.com.
  • Knöll R; Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden. daniela.spaeter@astrazeneca.com.
  • Hidalgo A; Bioscience Cardiovascular, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Yeh ST; Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden.
  • Elbeck Z; Bioscience Cardiovascular, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Silljé HHW; Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden.
  • Eijgenraam TR; Murdoch Children's Research Institute (MCRI), Flemington, Melbourne, VIC, Australia.
  • Siga H; Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia.
  • Zurek M; Ionis Pharmaceuticals, Carlsbad, CA, USA.
  • Palmér M; Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden.
  • Pehrsson S; Department of Cardiology University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Albery T; Department of Cardiology University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Bomer N; Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden.
  • Hoes MF; Bioscience Cardiovascular, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Boogerd CJ; Bioscience Cardiovascular, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Frisk M; Laboratory of Experimental Biomedicine, Core Facilities, Sahlgrenska Academy, Gothenburg University, Göteborg, Sweden.
  • van Rooij E; Bioscience Cardiovascular, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Damle S; Bioscience Cardiovascular, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Louch WE; Department of Cardiology University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Wang QD; Department of Cardiology University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Fritsche-Danielson R; Department of Molecular Cardiology, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center Utrecht, Utrecht, The Netherlands.
  • Chien KR; Institute for Experimental Medical Research, Oslo University Hospital and KG Jebsen Center for Cardiac Research, University of Oslo, Oslo, Norway.
  • Hansson KM; Department of Molecular Cardiology, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center Utrecht, Utrecht, The Netherlands.
  • Mullick AE; Ionis Pharmaceuticals, Carlsbad, CA, USA.
  • de Boer RA; Institute for Experimental Medical Research, Oslo University Hospital and KG Jebsen Center for Cardiac Research, University of Oslo, Oslo, Norway.
  • van der Meer P; Bioscience Cardiovascular, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Nat Commun ; 12(1): 5180, 2021 08 30.
Article em En | MEDLINE | ID: mdl-34462437
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Ligação ao Cálcio / Terapia Genética / Oligonucleotídeos Antissenso / Insuficiência Cardíaca / Cardiomiopatias Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Ligação ao Cálcio / Terapia Genética / Oligonucleotídeos Antissenso / Insuficiência Cardíaca / Cardiomiopatias Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article