An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of cathepsin L: KGP94.

Munikishore, Rachakunta; Wang, Liang-Liang; Zhang, Shuqun; Zhao, Qin-Shi; Zuo, Zhili

Munikishore, Rachakunta; Wang, Liang-Liang; Zhang, Shuqun; Zhao, Qin-Shi; Zuo, Zhili.

Afiliação

Munikishore R; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650 201, Yunnan province, People's Republic of China.
Wang LL; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650 201, Yunnan province, People's Republic of China. Electronic address: wangliangliang@mail.kib.ac.cn.
Zhang S; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650 201, Yunnan province, People's Republic of China.
Zhao QS; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650 201, Yunnan province, People's Republic of China.
Zuo Z; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650 201, Yunnan province, People's Republic of China. Electronic address: zuozhili@mail.kib.ac.cn.

Bioorg Chem ; 116: 105317, 2021 11.

Article em En | MEDLINE | ID: mdl-34488126

Assuntos

Catepsina L/antagonistas & inibidores; Inibidores Enzimáticos/farmacologia; Bibliotecas de Moléculas Pequenas/farmacologia; Tiossemicarbazonas/farmacologia; Tioureia/análogos & derivados; Catepsina L/metabolismo; Relação Dose-Resposta a Droga; Inibidores Enzimáticos/síntese química; Inibidores Enzimáticos/química; Humanos; Estrutura Molecular; Bibliotecas de Moléculas Pequenas/síntese química; Bibliotecas de Moléculas Pequenas/química; Relação Estrutura-Atividade; Tiossemicarbazonas/síntese química; Tiossemicarbazonas/química; Tioureia/síntese química; Tioureia/química; Tioureia/farmacologia

Palavras-chave

Cathepsin L; KGP94, cancer; gram-scale synthesis; small-molecule inhibitor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiossemicarbazonas / Tioureia / Inibidores Enzimáticos / Bibliotecas de Moléculas Pequenas / Catepsina L Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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