3D Hydrazone-Functionalized Covalent Organic Frameworks as pH-Triggered Rotary Switches.
Small
; 17(41): e2102630, 2021 10.
Article
em En
| MEDLINE
| ID: mdl-34510728
ABSTRACT
The property expansion of 3D functionalized covalent organic frameworks (COFs) is important for developing their potential applications. Herein, the first case of 3D hydrazone-decorated COFs as pH-triggered molecular switches is reported, and their application in the stimuli-responsive drug delivery system is explored. These functionalized COFs with hydrazone groups on the channel walls are obtained via a multi-component bottom-up synthesis strategy. They exhibit a reversible E/Z isomerization at various pH values, confirmed by UV-vis absorption spectroscopy and proton conduction. Remarkably, after loading cytarabine (Ara-C) as a model drug molecule, these pH-responsive COFs show an excellent and intelligent sustained-release effect with an almost fourfold increase in the Ara-C release at pH = 4.8 than at pH = 7.4, which will effectively improve drug-targeting. Thus, these results open a way toward designing 3D stimuli-responsive functionalized COF materials and promote their potential application as drug carriers in the field of disease treatment.
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MEDLINE
Assunto principal:
Estruturas Metalorgânicas
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article