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Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode.
Down, Kenneth; Amour, Augustin; Anderson, Niall A; Barton, Nick; Campos, Sebastien; Cannons, Edward P; Clissold, Cole; Convery, Maire A; Coward, John J; Doyle, Kevin; Duempelfeld, Birgit; Edwards, Christopher D; Goldsmith, Michael D; Krause, Jana; Mallett, David N; McGonagle, Grant A; Patel, Vipulkumar K; Rowedder, James; Rowland, Paul; Sharpe, Andrew; Sriskantharajah, Srividya; Thomas, Daniel A; Thomson, Douglas W; Uddin, Sorif; Hamblin, J Nicole; Hessel, Edith M.
Afiliação
  • Down K; Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
  • Amour A; Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
  • Anderson NA; Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
  • Barton N; Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
  • Campos S; Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
  • Cannons EP; Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
  • Clissold C; Charles River Discovery, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Convery MA; Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
  • Coward JJ; Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
  • Doyle K; Charles River Discovery, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Duempelfeld B; Cellzome GmbH, A GlaxoSmithKline Company, Meyerhofstraße 1, Heidelberg 69117, Germany.
  • Edwards CD; Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
  • Goldsmith MD; Charles River Discovery, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Krause J; Cellzome GmbH, A GlaxoSmithKline Company, Meyerhofstraße 1, Heidelberg 69117, Germany.
  • Mallett DN; Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
  • McGonagle GA; Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
  • Patel VK; Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
  • Rowedder J; Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
  • Rowland P; Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
  • Sharpe A; Charles River Discovery, Chesterford Research Park, Saffron Walden CB10 1XL, U.K.
  • Sriskantharajah S; Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
  • Thomas DA; Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
  • Thomson DW; Cellzome GmbH, A GlaxoSmithKline Company, Meyerhofstraße 1, Heidelberg 69117, Germany.
  • Uddin S; Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
  • Hamblin JN; Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
  • Hessel EM; Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
J Med Chem ; 64(18): 13780-13792, 2021 09 23.
Article em En | MEDLINE | ID: mdl-34510892
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfonamidas / Classe I de Fosfatidilinositol 3-Quinases / Inibidores de Fosfoinositídeo-3 Quinase Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfonamidas / Classe I de Fosfatidilinositol 3-Quinases / Inibidores de Fosfoinositídeo-3 Quinase Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article