Electro-Oxidative C-N Bond Formation through Azolation of Indole Derivatives: An Access to 3-Substituent-2-(Azol-1-yl)indoles.
J Org Chem
; 86(22): 16059-16067, 2021 11 19.
Article
em En
| MEDLINE
| ID: mdl-34520191
ABSTRACT
A practical protocol to synthesize 3-substituent-2-(azol-1-yl)indole derivatives has been developed via an electrochemical oxidative cross coupling process under mild conditions. This electro-oxidative C-N bond formation strategy tolerates a range of functional groups and is amenable to gram scale synthesis. Moreover, this method was applied to the late-stage functionalization of bioactive molecules.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Danazol
/
Indóis
Tipo de estudo:
Guideline
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article