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Modeling Human Genetic Disorders with CRISPR Technologies in Xenopus.
Willsey, Helen Rankin; Guille, Matthew; Grainger, Robert M.
Afiliação
  • Willsey HR; Department of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California 94143, USA; helen.willsey@ucsf.edu rmg9p@virginia.edu.
  • Guille M; European Xenopus Resource Centre, School of Biological Sciences, University of Portsmouth, Portsmouth PO1 2UP, United Kingdom.
  • Grainger RM; Department of Biology, University of Virginia, Charlottesville, Virginia 22904, USA helen.willsey@ucsf.edu rmg9p@virginia.edu.
Cold Spring Harb Protoc ; 2022(3)2022 03 01.
Article em En | MEDLINE | ID: mdl-34531330
ABSTRACT
Combining the power of Xenopus developmental biology with CRISPR-based technologies promises great discoveries in understanding and treating human genetic disorders. Here we provide a practical pipeline for how to go from known disease gene(s) or risk gene(s) of interest to methods for gaining functional insight into the contribution of these genes to disorder etiology in humans.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistemas CRISPR-Cas / Edição de Genes Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistemas CRISPR-Cas / Edição de Genes Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article