Discovery and development of CPL207280 as new GPR40/FFA1 agonist.
Eur J Med Chem
; 226: 113810, 2021 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-34537444
ABSTRACT
Due to a unique mechanism that limits the possibility of hypoglycemia, the free fatty acid receptor (FFA1) is an attractive target for the treatment of type 2 diabetes. So far, however, none of the promising agonists have been able to enter the market. The most advanced clinical candidate, TAK-875, was withdrawn from phase III clinical trials due to liver safety issues. In this article, we describe the key aspects leading to the discovery of CPL207280 (13), the design of which focused on long-term safety. The introduction of small, nature-inspired acyclic structural fragments resulted in compounds with retained high potency and a satisfactory pharmacokinetic profile. Optimized synthesis and upscaling provided a stable, solid form of CPL207280-51 (45) with the properties required for the toxicology studies and ongoing clinical trials.
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Base de dados:
MEDLINE
Assunto principal:
Caproatos
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Receptores Acoplados a Proteínas G
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Desenvolvimento de Medicamentos
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article